Expression of COX-2 and hsp72 in peritoneal macrophages after an acute ochratoxin A treatment in mice

Life Sciences
Maria Carmela FerranteR Meli

Abstract

Ochratoxin A (OTA) is a secondary fungal metabolite produced by Aspergillus and Penicillium strains that elicits a broad spectrum of toxicological effects in animals and man. A single oral OTA administration (10 mg/kg) in mice induced after 24 h oxidative damage and polymorphonuclear leukocyte (PMN) infiltration in parenchymal organs. In fact, OTA treatment increased lipid peroxidation (via malondialdehyde formation) in kidney and liver and PMN accumulation in duodenum, as shown by myeloperoxidase activity. Following in vivo OTA treatment an increase of cyclooxygenase-2 and of heat shock protein 72 expression was evidenced in peritoneal macrophage lysates by Western blot. That OTA modulates these proteins involved in the inflammatory process indicates that the mycotoxin is able to activate immune cells. This study suggests that the oxidative stress, the neutrophil accumulation in parenchymal tissues and the modulation of inflammatory parameters in peritoneal macrophages induced by OTA are involved in its toxicity, and represent early events related to several aspects of OTA mycotoxicosis.

References

Nov 1, 1990·Journal of Comparative Pathology·G S SinghK K Singh
Dec 1, 1988·Biochemical Pharmacology·A D RahimtulaH Bartsch
Mar 13, 1965·Nature·K J van der MerweJ J Theron
Feb 1, 1984·Toxicology and Applied Pharmacology·S C LeeF S Chu
Feb 1, 1984·Toxicology and Applied Pharmacology·G A BoormanM I Luster
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K SeibertP Isakson
Nov 1, 1993·American Journal of Medical Genetics·X Wei, K K Sulik
Nov 1, 1996·The Journal of Biological Chemistry·D HoehlerH Xiao
Jul 22, 1998·European Journal of Pharmacology·R ZamoraA G Herman
Dec 16, 1998·Archives of Toxicology·A BelmadaniE E Creppy
Nov 24, 1999·Chemical Research in Toxicology·I G GillmanR A Manderville
Dec 22, 1999·Biochemical Pharmacology·M G Santoro
Nov 15, 2001·FEBS Letters·A IanaroM Di Rosa
Feb 28, 2002·Circulation·A Graham Pockley
May 25, 2002·Archives of Toxicology·Karmela BarisićTihana Zanić Grubisić
Jun 7, 2002·Immunity·Wim Van MolleClaude Libert
Oct 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuseok Moon, James J Pestka
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Saulo Klahr, Jeremiah Morrissey
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L AlvarezA López de Cerain
Apr 15, 2004·Journal of Agricultural and Food Chemistry·Terry VrabchevaSylviane Dragacci
Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qunshan Jia, James J Pestka

❮ Previous
Next ❯

Citations

Jul 22, 2011·Journal of Toxicology·M Marin-KuanB Schilter
Oct 28, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C A González-AriasA J Ramos
Sep 24, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Se-Young OhNiel A Karrow
Jun 17, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maja Segvić KlarićLada Rumora
Dec 14, 2018·Human & Experimental Toxicology·D RašićM Peraica
May 20, 2020·Environmental Science and Pollution Research International·Kamal NiazMohammed Bule
May 1, 2021·Frontiers in Microbiology·Rhys BrownJonathan P Richardson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicological Sciences : an Official Journal of the Society of Toxicology
Christophe CavinB Schilter
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C Boesch-SaadatmandiG Rimbach
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A ThuvanderI Gadhasson
© 2022 Meta ULC. All rights reserved