PMID: 11917224Mar 28, 2002Paper

Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomas

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Q Jackie CaoJoan G Jones

Abstract

COX-2, the isoform of cyclooxygenase inducible by cytokines, mitogens, and growth factors, appears to play an important role in inflammation and carcinogenesis. In the colon, COX-2 overexpression results in cell cycle alterations, and NSAIDs have proven effective in cancer chemoprevention. HNPCC (hereditary nonpolyposis colon cancer) is a clinically defined cancer susceptibility syndrome in which women are also at significantly increased risk for the development of endometrial carcinoma. The purpose of this study was to evaluate expression of COX-2 in benign and malignant endometrium in the context of other cell cycle and proliferation markers, including Ki-67, cyclin D1, and the cyclin-dependent kinase inhibitor, p21. Immunostains with COX-2, Ki-67, cyclin D1, and p21 antibodies were performed on formalin-fixed and paraffin-embedded tissue sections from 40 cases: 10 benign (5 atrophic and 5 proliferative) endometria, 6 hyperplasias (complex without atypia), and 24 endometrioid carcinomas (9 well, 4 moderately, and 11 poorly differentiated). Ki-67 was positive in all proliferative and neoplastic endometria. Cyclin D1 and p21 were both overexpressed in endometrial hyperplasia and endometrioid carcinomas. COX-2 was negative in th...Continue Reading

Associated Clinical Trials

References

Nov 18, 1994·Cell·C J Sherr
May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Feb 3, 1999·Lancet·C J Hawkey
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KogaM Sata
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H B SalvesenL A Akslen
May 26, 1999·The Journal of Pathology·J BartekJ Bartkova
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Jun 1, 2000·Gynecologic Oncology·M J SchmitzM J Birrer
Mar 10, 2001·Obstetrics and Gynecology·H A ArangoJ L Becker

❮ Previous
Next ❯

Citations

Mar 5, 2004·Chemistry and Physics of Lipids·Yong CuiKyoung-Chan Park
Mar 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Colin J R StewartMichael Platten
Apr 23, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joan FortunySara H Olson
Jan 14, 2003·Pharmacotherapy·Suphat SubongkotDeborah Drajer
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Gema Moreno-BuenoJosé Palacios
Dec 15, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Cornelia AmalineiIrina-Draga Caruntu
Jul 6, 2010·The Journal of Obstetrics and Gynaecology Research·Sevinç Hallaç KeserNimet Karadayi
Oct 13, 2006·Gynecologic Oncology·Serkan ErkanliEsra Kuscu
May 3, 2005·Gynecologic Oncology·Sokbom KangHyo Pyo Lee
Oct 31, 2014·Diagnostic Cytopathology·Polyxeni Nicolopoulou-StamatiAnna Maria Athanassiadou
Apr 23, 2005·American Journal of Obstetrics and Gynecology·Jeffrey M FowlerCarl Morrison
Dec 17, 2014·Journal of Postgraduate Medicine·C R ShevraM Kumar
Jan 18, 2014·American Journal of Clinical Pathology·Carlos Chaves FaloppaFernando Augusto Soares
Aug 9, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Elisabeth J M RobbeJohanna M A Pijnenborg
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Adnan Munkarah, Rouba Ali-Fehmi
Sep 5, 2003·Oncogene·Gema Moreno-BuenoJosé Palacios
Dec 15, 2005·The Journal of Pathology·Sanjana MehrotraSunil Badve
Sep 20, 2019·Current Pharmaceutical Biotechnology·Marcin OplawskiDariusz Boroń
Dec 7, 2016·Human Reproduction Update·Peter A SandersonPhilippa T K Saunders
Jun 18, 2021·Biomarker Research·Wenyu CaoQing Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.