Expression of CXCR-4 and IDO in human colorectal cancer: An immunohistochemical approach

Molecular and Clinical Oncology
Masaichi OgawaKatsuhiko Yanaga

Abstract

C-X-C chemokine receptor type 4 (CXCR4), the receptor for the chemokine stromal cell-derived factor (SDF)-1 [also known as C-X-C motif chemokine 12 (CXCL12)], is involved in lymphocyte trafficking. Recent studies have demonstrated that, during pregnancy, a placental enzyme called indoleamine 2, 3-dioxygenase (IDO) exerts a key role in suppressing the maternal T-cell response against the fetus. In the present study, the significance of CXCR4 and IDO expression in human colorectal cancer (CRC) has been investigated by immunohistochemical assay, and their association with survival was analyzed. Tumor specimens (n=60) from patients with different American Joint Committee on Cancer (AJCC) stages of CRC (I or IV) were assessed. In the stage IV group, 23 of 30 cases (77%) stained positive for CXCR4, and 9 of 30 (30%) were positive for IDO. By contrast, in the stage I group, 7 of 30 cases (23%) stained positive for CXCR4, and 15 of 30 cases (50%) were positive for IDO. The 5-year survival rate of those with high CXCR4 expression in tumor specimens (n=30) was significantly worse compared with those with negative CXCR4 expression (16.3 vs. 60.7%, P=0.02). By contrast, the 5-year survival rate of those with high IDO expression in tumor sp...Continue Reading

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Yoshida, O Hayaishi
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R YoshidaO Hayaishi
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E R Pfefferkorn
May 23, 1998·FEBS Letters·A CaruzF Arenzana-Seisdedos
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Jul 10, 2003·Immunology and Cell Biology·John R Moffett, Ma Aryan Namboodiri
Sep 2, 2004·Journal of Molecular Histology·Magda KuciaMariusz Z Ratajczak
Jan 11, 2005·Lancet·Jürgen WeitzMarkus W Büchler
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph KimDave S B Hoon
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aikou OkamotoMitsuyoshi Urashima
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gerald BrandacherAlbert Amberger
Apr 6, 2007·Cancer Research·Adi Zipin-RoitmanAdit Ben-Baruch
Apr 18, 2008·World Journal of Gastroenterology : WJG·Ji-Kun LiJian-Hai Zhang
Jun 27, 2008·Cancer Letters·Jo VandercappellenSofie Struyf
May 14, 2009·British Journal of Cancer·B CambienH Schmid-Antomarchi
Jul 2, 2009·Neoplasia : an International Journal for Oncology Research·Peter GassmannAnja Müller
Aug 22, 2009·Journal of Translational Medicine·Yan-Fang GaoXiao-Shi Zhang
Mar 17, 2010·The Journal of Biological Chemistry·Vikas SainiMatthias Majetschak
Sep 25, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vilma Oliveira FrickMartin K Schilling
Jan 8, 2011·Cancer Research·Kenji Kawada, Makoto M Taketo
Jun 13, 2012·International Journal of Cancer. Journal International Du Cancer·Teppei MurakamiYoshiharu Sakai
Sep 13, 2012·Experimental and Therapeutic Medicine·Nian-Hua ZhangRong-Cheng Luo

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