Expression of cyclin D1 in normal, metaplastic, hyperplastic endometrium and endometrioid carcinoma suggests a role in endometrial carcinogenesis.

Archives of Pathology & Laboratory Medicine
M Ruhul QuddusRoberto N Miranda

Abstract

Endometrioid carcinoma is often preceded by characteristic histopathologic lesions known as endometrial hyperplasia. Estrogen appears to be involved in the development of endometrioid carcinoma. Other mechanisms of endometrial carcinogenesis include mutations in p53 and PTEN tumor suppressor genes and overexpression of cyclin D1. However, the pattern of cyclin D1 expression is not well defined in normal, hyperplastic, neoplastic, and metaplastic endometrium. Cyclin D1 immunohistochemical analysis was used to evaluate 108 fixed, paraffin-embedded endometrial biopsy specimens and uterine resections obtained from 108 patients. Specimens included proliferative and secretory endometria, simple and complex hyperplastic lesions, and endometrioid adenocarcinoma. Normal and metaplastic surface epithelia were also evaluated independently of glandular morphologic features. Cyclin D1 was significantly overexpressed in glands with complex hyperplasia and endometrioid adenocarcinoma compared with proliferative or secretory endometrium and simple hyperplasia. Significant overexpression was also noted in papillary, syncytial, and squamous metaplasias compared with normal surface epithelium or epithelium with tubal metaplasia. Overexpression of...Continue Reading

References

Jan 1, 1992·Molecular Carcinogenesis·J I RisingerJ Boyd
Jul 1, 1992·American Journal of Clinical Pathology·M E BurP G Rose
Jul 1, 1984·Histopathology·S C Lauchlan
Jan 1, 1994·Genes, Chromosomes & Cancer·J KarlsederC Theillet
Nov 18, 1994·Cell·C J Sherr
Feb 1, 1993·British Journal of Cancer·W D FoulkesJ Trowsdale
Nov 1, 1993·Archives of Otolaryngology--head & Neck Surgery·M E WilliamsP A Levine
Jun 1, 1993·American Journal of Clinical Pathology·D J Gersell
Jun 1, 1993·American Journal of Clinical Pathology·S S Zaman, M T Mazur
Jan 8, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·T ShiozawaS Fujii
Aug 26, 1998·The American Journal of Surgical Pathology·B S KendallR J Kurman
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M E Sherman
Jun 8, 2000·Journal of the National Cancer Institute·G L MutterC Eng
Dec 8, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G L Mutter
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R N MirandaJ B Cousar

❮ Previous
Next ❯

Citations

May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan M Kurie
Dec 8, 2006·Archives of Pathology & Laboratory Medicine·Roberto N MirandaEmad Kaabipour
Sep 5, 2003·Oncogene·Gema Moreno-BuenoJosé Palacios
Apr 14, 2012·The American Journal of Surgical Pathology·Teresa AlvarezEsther Oliva
Dec 13, 2003·Cancer Letters·Andrzej Semczuk, Jerzy Andrzej Jakowicki
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Gema Moreno-BuenoJosé Palacios
May 3, 2005·Gynecologic Oncology·Sokbom KangHyo Pyo Lee
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F KayaselcukB Demirhan
Dec 20, 2005·Human Reproduction·O C PillayP Hardiman
Aug 4, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·W WuK H Lu
Feb 25, 2009·Journal of Cellular Physiology·James M Haughian, Andrew P Bradford
Jun 6, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kimberly H AllisonRochelle L Garica
Mar 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Colin J R StewartMichael Platten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.