PMID: 7545645Sep 1, 1995Paper

Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/cyclin D1 gene

Human Pathology
S H SwerdlowM E Williams

Abstract

Centrocytic/mantle cell lymphoma (CC/MCL) is a morphologically defined B-cell non-Hodgkin's lymphoma characterized by a distinctive immunophenotype, BCL1/cyclin D1 (PRAD1) gene rearrangements, and, most recently, by overexpression of cyclin D1. Even using multiple breakpoint probes for BCL1 (MTC, p94PS) and cyclin D1, however, only approximately 70% of CC/MCL have a rearrangement consistent with a t(11;14) (q13;q32). To determine whether the type of molecular translocation affects the degree of cyclin D1 expression and to evaluate lymphomas diagnosed as CC/MCL but lacking molecular evidence of a BCL1 or cyclin D1 translocation, 16 CC/MCL and four cases of small lymphocytic lymphoma/B-CL1 (SLL/B-CLL) were stained using an anti-cyclin D1 antibody. All cases with a cyclin D1 translocation detected by Southern blotting techniques as well as four of the five CC/MCL without a documentable translocation showed nuclear cyclin D1 protein expression. There was no apparent correlation between staining intensity and the precise site or presence of a detectable translocation. Cases with a mantle zone growth pattern showed infiltration of the cyclin D1 positive cells into reactive follicular centers. None of the four SLL/B-CLL showed cyclin ...Continue Reading

Citations

Jun 13, 1998·Molecular Pathology : MP·R Donnellan, R Chetty
Dec 15, 2010·Acta histochemica·Sarah E HensonCindy S Malone
Sep 22, 2012·British Journal of Haematology·P McKayUNKNOWN British Committee for Standards in Haematology
Jun 14, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Zainalabideen AbdullaFrancesco Pezzella
Dec 1, 1996·Baillière's Clinical Haematology·L Mauvieux, E A Macintyre
Apr 6, 2004·Leukemia & Lymphoma·Mathias J RummelWolf-K Hofmann
Oct 6, 2005·Leukemia Research·L Jeffrey MedeirosGeorge Z Rassidakis
Jul 26, 2011·Seminars in Hematology·Boris A RatschGeorg Lenz
Sep 18, 2007·Annals of Diagnostic Pathology·Kedar V Inamdar, Carlos E Bueso-Ramos
May 22, 2010·La Revue de médecine interne·S Le Gouill
Feb 26, 2000·British Journal of Haematology·F PezzellaK C Gatter
Jun 3, 1998·British Journal of Haematology·R FonsecaP R Greipp
Jul 28, 2004·Journal of the American College of Surgeons·E Ramsay CampSteven N Hochwald
Aug 7, 2002·American Journal of Clinical Pathology·Zach LiuJames Weisberger
Jul 11, 2001·Advances in Anatomic Pathology·E D Hsi, S Yegappan
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Nuno CerveiraSérgio Castedo
Aug 3, 2002·Leukemia & Lymphoma·Didier Decaudin
Feb 13, 2018·Case Reports in Pathology·Uzma Mohammad SiddiquiMira S Torres
Jun 30, 2000·American Journal of Clinical Pathology·J D HoyerP J Kurtin
Aug 1, 1996·Clinical Molecular Pathology·C D Fegan, F E Davies
Jul 1, 1997·Pathology International·S NakamuraM Seto
Feb 17, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C SambadeC Sundström
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou
Mar 22, 2006·Oncogene·K E KnudsenE S Knudsen
Aug 29, 2006·Oncogene·L LeonciniG De Falco
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R N MirandaJ B Cousar

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