PMID: 9531999Apr 9, 1998Paper

Expression of cyclin D1, retinoblastoma gene protein, and p16 MTS1 protein in atypical adenomatous hyperplasia and adenocarcinoma of the lung. An immunohistochemical analysis

Virchows Archiv : an International Journal of Pathology
Y KurasonoH Kitamura

Abstract

To clarify the events leading to the disruption of cell growth control that occurs during the development of pulmonary adenocarcinoma (AC), we used immunohistochemistry to evaluate the expression of G1 cycle regulators, cyclin D1, Rb protein (pRb), and p16 MTS1 protein and the tumour proliferation marker, Ki 67, both in AC of the lung and in its precursor lesion, atypical adenomatous hyperplasia (AAH). The frequency of lesions with cyclin D1 overexpression was relatively high in AAH (47-89%), but was decreased in early AC (28%) and overt AC (35%). The loss of pRb expression was rare in both AAH (0-18%) and early AC (0%), and was infrequent even in overt AC (13%). The loss of p16 expression was also relatively infrequent in both the premalignant and the malignant lesions (11-25%). Our results suggest that overexpression of cyclin D1 is an early event and plays an important part in tumorigenesis in the case of lung AC. However, cyclin D1 overexpression is not required for the development and maintenance of a malignant phenotype. It is likely that some cyclin D1-independent pathways other than Rb and p16 abnormalities have an important role in the malignant transformation from AAH to early AC.

Citations

May 17, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N ZojerH Huber
Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·V RigauJ M Bréchot
Mar 28, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masaki TominagaEisaburo Sueoka
Apr 18, 2001·Journal of Clinical Pathology·K M Kerr
Feb 20, 2003·AJR. American Journal of Roentgenology·Shodayu TakashimaShusuke Sone
Mar 22, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Chang Min ParkJung-Gi Im
Oct 31, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Oliver GautschiJim Heighway
May 16, 2009·International Journal of Surgical Pathology·Aikaterini MastorakiKiriaki Aroni
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M MoriA E Fraire
May 1, 2002·Respiratory Research·Alissa K GreenbergWilliam N Rom
Aug 20, 2020·Histopathology·Koji OkudelaKenichi Ohashi
Dec 22, 2004·Cancer·Ryota TanakaMasayuki Noguchi

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