Expression of cyclo-oxygenase 1 and 2 proteins in upper respiratory mucosa

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
P DemolyJ Bousquet

Abstract

Cyclo-oxygenases 1 (Cox-1) and 2 (Cox-2) catalyse the conversion of arachidonic acid to prostaglandin endoperoxides, leading to the formation of prostaglandin and thromboxane mediators of inflammation. The involvement of these enzymes in inflammatory disorders such as sinusitis and nasal polyps is unknown although this may be relevant to their pathophysiology. We studied Cox-1 and Cox-2 immunoreactivities in nasal polyp, maxillary sinus, and turbinate biopsies obtained from eight patients with chronic allergic rhinitis and sinusitis and/or nasal polyps, 15 patients with chronic non-allergic rhinitis and sinusitis and/or nasal polyps and five control subjects (patients requiring nose surgery not related to sinusitis or nasal polyps). Both Cox- and Cox-2 were mainly expressed in the epithelium (basal, ciliated) and were found in 16/28 and 25/28 subjects for Cox-1 and Cox-2 respectively. We did not find any differences between the patient populations. There were no correlations between any of the clinical parameters studied nor the pathological patterns and the presence and characteristics of the Cox immunoreactivities. Both cyclo-oxygenase enzymes are expressed in normal human upper respiratory epithelium and are not upregulated ...Continue Reading

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Citations

May 21, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroichi Nagai
Jul 1, 2008·Current Allergy and Asthma Reports·Josep M GuilemanyJoaquim Mullol
Oct 1, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Demet YaziciAysun Uğuz
Jul 23, 2015·Journal of Strength and Conditioning Research·Patrick B Wilson
Aug 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M OkanoK Nishizaki
May 21, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J ShiP J Thompson
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C Fernández-MorataC Picado
Jan 22, 2002·The Annals of Otology, Rhinology, and Laryngology·Chang-Bae YunTae-Jung Jang
Aug 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Louise S HarringtonJane A Mitchell
Feb 14, 2009·American Journal of Respiratory Cell and Molecular Biology·Cecilia EstrellaPhilippe Gosset
Feb 28, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jordi Roca-FerrerCesar Picado
Jan 1, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Monique VorsprachJens Schreiber
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Mar 15, 2011·The Journal of Allergy and Clinical Immunology·Jordi Roca-FerrerCesar Picado

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