Expression of cyclooxygenase-2 (COX-2) and Ki67 as related to disease severity and HPV detection in squamous lesions of the cervix

Gynecologic Oncology
Luis Otavio SarianLiliana Aparecida Lucci De Angelo Andrade

Abstract

To assess the expression of cyclooxygenase (COX-2) and Ki67 in cervical squamous lesions in relation to disease severity and human papillomavirus (HPV) detection. For this cross-sectional study, 223 women subjected to diathermic conization of the cervix have been enrolled, between February 2001 and April 2004. All patients undertook pelvic examination, including colposcopy and collection of samples for Hybrid Capture II (HCII). Pathological assessment disclosed: 9 cases of normal epithelium/cervicitis, 33 CIN1, 28 CIN2, 146 CIN3 and 7 invasive squamous cell carcinomas. COX-2 and Ki67 protein expression was determined with immunohistochemistry. COX-2 immunoreactivity grading was based on the German ImmonoReactive score. The continuum percentage of positive cells was used for the assessment of nuclear Ki67 expression. Expression of COX-2 did not correlate with disease severity and with Ki67 expression. The HPV detection rates did not differ significantly across COX-2 protein expression strata, ranging from negative to strong expression. Ki67 expression, however, was higher in the CIN3 group (P = 0.001) as compared to the specimens rendered as normal/cervicitis. COX-2 protein expression did not correlate with disease severity or K...Continue Reading

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Citations

Jul 28, 2010·The American Journal of Surgical Pathology·Mary T GalganoMark H Stoler
Dec 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Andrea CiavattiniGaia Goteri
Aug 7, 2010·Biochemical and Biophysical Research Communications·Sawali R SudarshanXuefeng Liu
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Jun-Sang KimMoon-June Cho
Sep 6, 2008·Diagnostic Cytopathology·Priscila Garcia FigueiredoSophie Derchain
Aug 2, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N KuboY Maehara
Apr 20, 2011·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Luciane Noal CalilMary Clarisse Bozzetti
Jul 3, 2019·International Journal of Cancer. Journal International Du Cancer·Cecilie D de la CourSusanne K Kjaer
Nov 13, 2008·Expert Review of Molecular Diagnostics·Laoighse MulraneWilliam M Gallagher

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