Expression of cyclooxygenase-2 in epithelial ovarian tumors and its relation to vascular endothelial growth factor and p53 expression

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
J S LeeK W Min

Abstract

The purpose of this study was to evaluate cyclooxygenase-2 (COX-2) expression in epithelial ovarian tumors and its correlation with vascular endothelial growth factor (VEGF) and p53 expression. Immunohistochemical studies with anti-COX-2, anti-VEGF, and anti-p53 antibodies were carried out in 54 malignant and 23 borderline epithelial ovarian tumors. Elevated COX-2 expression was detected in 77.8% of ovarian carcinomas, which was significantly higher than that of borderline tumors (26.1%) (P < 0.001). In ovarian carcinomas, there was no significant correlation between COX-2 expression and other clinicopathologic features. Elevated VEGF expression was detected in 74.1% of ovarian carcinomas, and p53 expression was found in 64.8% of ovarian carcinomas. COX-2 expression was statistically correlated with elevated VEGF expression (P < 0.001) and p53 positivity (P < 0.05). On a univariate analysis, FIGO stage (P < 0.0001), histologic type (P= 0.0104), and COX-2 expression (P= 0.0135) were significant prognostic factors for overall survival. In a multivariate analysis, FIGO stage (P < 0.0001) was the only independent prognostic factor for poor survival. These findings suggest that COX-2 may play a role in the progression of epithelial ...Continue Reading

References

Jan 24, 1998·Lancet·D W CramerE R Greenberg
Jan 19, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W H WenM F Press
Apr 10, 1999·The Journal of Biological Chemistry·K SubbaramaiahA J Dannenberg
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Jan 19, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S G Silverberg
Jun 20, 2001·The Journal of Clinical Investigation·W L Smith, R Langenbach
Jan 17, 2002·The Journal of Pathology·Bastiaan P van ReesG Johan A Offerhaus
Mar 14, 2002·The American Journal of Pathology·Carsten DenkertSteffen Hauptmann
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DaviesM Dowsett
Dec 11, 2002·The Journal of Surgical Research·Balraj Singh, Anthony Lucci
Jul 24, 2003·The American Journal of Pathology·Oreste GalloSergio Capaccioli
Oct 22, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hyung-Seok KimChang-Soo Park
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tiina-Liisa ErkinheimoAri Ristimäki

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Citations

Dec 15, 2010·International Journal of Molecular Sciences·Wei LiLing-Yun Zhai
Jun 30, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Joseph Menczer
Dec 18, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Louise BaandrupSusanne K Kjaer
Jul 22, 2009·International Journal of Cancer. Journal International Du Cancer·Shahab UddinAdnan Munkarah
May 26, 2006·Biochemical and Biophysical Research Communications·L A PerrymanP J Russell
May 5, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiangyang Zeng, Shuijing Yi

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