PMID: 11920595Mar 29, 2002Paper

Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder

International Journal of Cancer. Journal International Du Cancer
T KawamotoM Miwa

Abstract

Postsurgical recurrence at distant sites frequently occurs in pathological tumor stage 2 (pT(2)) carcinoma of the gallbladder even though the carcinoma is limited to the gallbladder wall. Little is known, however, about the molecular events leading to its development and progression. A large body of evidence suggests that cyclooxygenase-2 (COX-2) is up-regulated in carcinoma tissues and plays roles in promoting cell-proliferation, growth and metastasis of carcinoma cells. In the present study, immunohistochemistry was performed to determine the expression levels of COX-2 in the subserosal layer of 33 cases of pT(2) gallbladder carcinoma in which curative resections had been performed and to determine the correlations of the expression levels of COX-2 with mode of recurrence and postsurgical survival. Immunostaining of COX-2 in the epithelia was recognized in more than 80% of normal epithelia, noncancerous pathological lesions of the gallbladder except for intestinal metaplasia and pT(1-4) carcinoma specimens. Intense staining was observed in large percentages of hyperplastic lesions (65%), pT(2) carcinoma specimens (76%) and pT(3) and pT(4) carcinoma specimens (64%) compared to the percentages of normal epithelia and other path...Continue Reading

References

Jun 1, 1977·British Journal of Cancer·A BennettT Zebro
May 1, 1991·World Journal of Surgery·F P GallW Hohenberger
Apr 24, 1991·Biochimica Et Biophysica Acta·W L Smith, L J Marnett
Feb 1, 1990·Archives of Surgery·J H DonohueM A Adson
Dec 1, 1988·Journal of Surgical Oncology·K WhiteM J Lopez
May 1, 1994·European Journal of Biochemistry·T KosakaT Tanabe
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·W KutcheraS M Prescott
Feb 1, 1997·The British Journal of Surgery·K YamaguchiM Tanaka
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
Nov 14, 1997·Science·W K Hong, M B Sporn
Jun 11, 1999·The British Journal of Surgery·T TodorokiK Fukao
Oct 3, 1999·International Journal of Cancer. Journal International Du Cancer·H BambaF Matsuzaki
Dec 29, 2000·Seminars in Surgical Oncology·D L Bartlett

❮ Previous
Next ❯

Citations

Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Junichi ShodaNaomi Tanaka
Sep 3, 2004·Nature Reviews. Cancer·Ignacio I Wistuba, Adi F Gazdar
Feb 2, 2013·Archives of Pathology & Laboratory Medicine·Patricia GarciaJuan C Roa
May 1, 2008·Expert Opinion on Medical Diagnostics·Priya RupeshShukla Vijay Kumar
Aug 14, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Motoaki NaganoKazuo Chijiiwa
Oct 1, 2010·Surgical Oncology·Sanjeev K MauryaHari S Shukla
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Qinzhong ChenTomohiko Koyanagi
Jun 11, 2008·Molecular Carcinogenesis·Patricia GarcíaJuan Carlos Roa
Jun 9, 2012·Journal of Hepato-biliary-pancreatic Sciences·Junichi ShodaToru Kawamoto
Feb 13, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Shigeo HayashiJunji Takada
Mar 24, 2007·The Journal of Medical Investigation : JMI·Yoshitaka ImotoMitsuo Shimada
Jun 28, 2017·World Journal of Gastroenterology : WJG·Aarti SharmaAshok Kumar
Apr 3, 2021·Annals of Diagnostic Pathology·Alka Mary MathaiMatthew M Yeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.