Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions

The British Journal of Dermatology
A E C KiszewskiR Hernández Pando

Abstract

Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. To compare the COX-2 expression in LL and TL. Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0.001 by Student's t-test). The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy.

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Citations

Dec 16, 2011·The American Journal of the Medical Sciences·Khanh vinh quôc Luʼoʼng, Lan Thi Hoàng Nguyên
Dec 4, 2012·Prostaglandins & Other Lipid Mediators·Hong LiDarryl C Zeldin
Jan 16, 2007·International Journal of Experimental Pathology·Mayra Silva MirandaOscar Rojas-Espinosa
May 20, 2011·Clinical and Experimental Immunology·J de Souza SalesE N Sarno
Mar 14, 2017·Future Microbiology·Gurkamaljit Kaur, Jagdeep Kaur
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·Katherine Antunes de MattosPatricia T Bozza

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