Expression of CYP19 (aromatase) mRNA in the human temporal lobe

Biochemical and Biophysical Research Communications
B Stoffel-WagnerD Klingmüller

Abstract

The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in various animal species, but studies in human postnatal brain tissue are lacking. Therefore, we investigated CYP19 mRNA expression in human temporal lobe tissues. We studied biopsy materials removed at neurosurgery from 34 women, 32 men and 10 children with temporal lobe epilepsy. Quantification of CYP19 mRNA was achieved by nested competitive reverse transcription-PCR. CYP19 mRNA concentrations did not differ significantly between women (2.6 +/- 0.6 arbitrary units, aU; mean +/- SEM) and men (1.6 +/- 0.3 aU) nor between cerebral cortex tissue (2.0 +/- 0.4 aU) and subcortical white matter tissue of adults (2.4 +/- 0.7 aU), but they were significantly lower in cerebral cortex specimens of children (0.9 +/- 0.6 aU) than in those of adults (p < 0.02). In conclusion, CYP19 mRNA is expressed in the temporal lobe of children and adults. CYP19 mRNA concentrations are significantly lower in specimens of children than in those of adults.

References

Jan 1, 1978·Endocrinology·F W GeorgeJ D Wilson
Sep 1, 1992·Brain Research. Molecular Brain Research·N HaradaJ Balthazart
Nov 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·L Martini, R C Melcangi
Oct 1, 1990·Biology of Reproduction·P B ConnollyJ A Resko
Apr 30, 1990·Brain Research·J BalthazartN Harada
Dec 1, 1989·American Journal of Obstetrics and Gynecology·K J Doody, B R Carr
Jan 1, 1987·Journal of Steroid Biochemistry·L M Garcia-SeguraF Naftolin
Aug 1, 1971·The Journal of Clinical Endocrinology and Metabolism·F NaftolinZ Petro
Dec 1, 1981·Journal of Steroid Biochemistry·N J MacLuskyS Franks
Feb 15, 1994·Biochemical and Biophysical Research Communications·S HondaY Takagi
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·Y OsawaC Yarborough
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J Balthazart, A Foidart
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·P Negri CesiL Martini
Feb 24, 1997·Biochemical and Biophysical Research Communications·M WatzkaB Stoffel-Wagner

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Citations

Feb 1, 2014·Psychopharmacology·Duncan SinclairCynthia Shannon Weickert
Feb 16, 2011·Neuroscience·I AzcoitiaL M Garcia-Segura
Nov 3, 2009·Neuroscience Letters·Helen T ButlerDonald J Lehmann
Jun 10, 2009·Frontiers in Neuroendocrinology·Jean Luc Do RegoHubert Vaudry
Jul 28, 2016·Current Opinion in Behavioral Sciences·Daniel M Vahaba, Luke Remage-Healey
Mar 3, 2004·Annals of the New York Academy of Sciences·Birgit Stoffel-Wagner
Jul 8, 2008·Journal of Neuroendocrinology·L M Garcia-Segura
Jan 24, 2006·Neuroscience·J G YagueI Azcoitia
Jul 19, 2014·PloS One·Nino TabatadzeCatherine S Woolley
Nov 14, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T J CummingsC M Hulette
May 3, 2013·Dementia and Geriatric Cognitive Disorders·S C JanickiJ H Lee
Dec 3, 1999·Journal of Neuroendocrinology·M WatzkaB Stoffel-Wagner
Nov 7, 2017·Cerebral Cortex·Carmen Perez-LasoAntonio Guillamon
Jul 11, 2020·International Journal of Molecular Sciences·Yvette Akwa

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