PMID: 7522949Oct 15, 1994Paper

Expression of cytokeratin 10, 13, and involucrin as prognostic factors in low stage squamous cell carcinoma of the uterine cervix

Cancer
P F van BommelD Ivanyi

Abstract

The identification of pretreatment markers with predictive significance for the presence of lymph node metastases and treatment outcome in low stage cancer of the uterine cervix is clinically important. Because the presence of differentiation-related markers varies in this type of cancer, the authors investigated whether loss of these markers is related to a poor clinical course. An indirect immunoperoxidase technique was applied to formalin fixed, paraffin embedded tissue sections of 80 patients with International Federation of Gynecology and Obstetrics Stage IB and IIA primary squamous cell cervical carcinomas for detection of expression of cytokeratin 10 and 13, and involucrin. Comparisons were made of the expression of each of these markers among 40 patients with regional node metastases and 40 age-matched patients with no lymph node metastases. Differences in the frequency of expression of these markers also were analyzed in relation to histopathologic characteristics, recurrence, and survival. Expression of cytokeratin 10, 13, and involucrin was found in 24, 64, and 53%, respectively, of all patients studied. The authors found no differences between patients with positive regional lymph nodes and those with negative lymph...Continue Reading

References

Jan 1, 1985·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·J J PutsF C Ramaekers
Sep 1, 1987·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P F van BommelJ P Neijt
Sep 1, 1981·The Journal of Cell Biology·S Banks-Schlegel, H Green
Jul 1, 1982·American Journal of Obstetrics and Gynecology·H H AllenR J Anderson
Apr 1, 1981·American Journal of Obstetrics and Gynecology·J ZanderC Kaufmann

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Citations

Sep 21, 2004·Virchows Archiv : an International Journal of Pathology·Cord LangnerRichard Zigeuner
Aug 12, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R HuD Lau
Nov 1, 1996·Journal of Dermatological Science·W ZhouT S Chan
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M A van EijkerenH J Geuze
Aug 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Sanniya FarrukhShahid Pervez
Mar 2, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·E-S XuC-T Hsu
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·M T RuffinD E Brenner

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