Expression of cytokeratins in Warthin's tumour (adenolymphoma) of parotid glands: specific detection of individual cytokeratin types by monoclonal antibodies

European Journal of Cancer. Part B, Oral Oncology
C LiM Mori

Abstract

This study evaluated the distribution of cytokeratins detected by monoclonal antibodies directed against individual keratin proteins in normal human salivary glands and epithelial tumour cells of Warthin's tumour arising in parotid glands to determine a more precise mapping of their cellular distribution. The normal salivary ducts showed the presence of cytokeratin 7, 8, 18 and 19 in the intercalated, striated and excretory ducts, the primary keratins of stratified and simple epithelia with a profile very similar to the non-cornified epithelium of the oral mucosa. The basally located cells of salivary gland ducts other than myoepithelial cells were reactive for keratins 7 and 19 suggesting a close similarity in profile of keratin in the basal cells of the oral epithelium. In Warthin's tumour, keratins 7, 8, 18 and 19 were consistently detected in the epithelial cells of the tumour, a profile with a tendency to mimic the same in normal ductal epithelium. The distribution, however, was diverse and a heterogeneity was observed in the basal and luminal cells of Warthin's tumour which differed even in different areas of the same tumour specimen.

References

Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M MoriY Okada
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H GustafssonL E Thornell
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·I DardickD L Brown
Jan 1, 1988·Ultrastructural Pathology·I DardickS H Dairkee
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
May 1, 1994·European Journal of Cancer. Part B, Oral Oncology·P R Morgan, L Su
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·I Dardick, A P Burford-Mason
Jun 1, 1993·European Journal of Biochemistry·F A van de KlundertH Bloemendal

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Citations

Jun 29, 2005·Pathology International·Ji-Hye LeeYang-Seok Chae
Dec 11, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mai P HoangMeera Mahalingam
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nikolaos G NikitakisOlga B Ioffe
Mar 21, 2001·The American Journal of Surgical Pathology·K J SmithH Skelton

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