Expression of cytokeratins, vimentin and basement membrane components in human fetal male müllerian duct and perimüllerian mesenchyme

Acta histochemica
G Magro, S Grasso

Abstract

The expression and distribution of cytokeratins 8, 18, 19, pan-cytokeratin, vimentin, type IV collagen, laminin and fibronectin were investigated immunohistochemically in the Wolffian and Müllerian ducts and perimüllerian mesenchyme of human male fetuses ranging from 8 to 12 weeks of gestation. The epithelial cells of both genital ducts, the coelomic epithelium and the mesenchymal perimüllerian cells coexpressed cytokeratins 18, 19, pancytokeratin and vimentin. Type IV collagen, laminin, and fibronectin were detected in the basement membranes of both genital ducts, the coelomic epithelium and in the interstitium of the perimüllerian mesenchyme. The coelomic basement membrane adjacent to the müllerian duct showed interruptions and perimüllerian cells were in contact with the coelomic epithelium. The cytoskeletal immunophenotype of perimüllerian cells and their relationship with the coelomic epithelium suggested their coelomic origin. During the 12th week of gestation, müllerian duct began to regress with its basement membrane detaching from the surrounding mesenchyme. This coincided with the disappearance of vimentin from the ductal epithelial cells, as well as type IV collagen, laminin and fibronectin from perimüllerian mesench...Continue Reading

References

Jul 1, 1977·The American Journal of Anatomy·J M PriceW H Hendren
Sep 1, 1989·American Journal of Medical Genetics·E D Hay
Jan 1, 1985·Differentiation; Research in Biological Diversity·J ParankoL J Pelliniemi

❮ Previous
Next ❯

Citations

Nov 1, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Elisabeth J PechrigglHelga Fritsch
Feb 26, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Elisabeth J PechrigglHelga Fritsch
May 1, 2007·Developmental Biology·Grant D Orvis, Richard R Behringer
Jan 20, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Zahida Yesmin RolyCraig A Smith
Oct 4, 2020·BMC Genomics·Zahida Yesmin RolyCraig A Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Related Papers

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
T AchtstätterW W Franke
Differentiation; Research in Biological Diversity
Gregory TasianLaurence S Baskin
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Martin J Cohn
© 2021 Meta ULC. All rights reserved