Expression of cytokine mRNA in leukemic cells from adult T cell leukemia patients

Japanese Journal of Cancer Research : Gann
T KodakaH Uchino

Abstract

HTLV-I infection of peripheral mature T cells appears to induce the expression of cellular genes including those of some cytokines and their receptors. We examined the expression of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-3, IL-4 and granulocyte/macrophage colony-stimulating factor (GM-CSF) at the mRNA level in fresh leukemic cells from 20 adult T cell leukemia patients to see whether there is any association between cytokine expression and HTLV-I expression and between their expression and clinical manifestations such as hypercalcemia or neutrophilia. IL-1 alpha, IL-1 beta and IL-3 expression was observed in 3, 7 and 1 of 20 cases examined, respectively. However, there seemed to be no association between IL-1 expression and clinical manifestations. IL-2, IL-4 and GM-CSF mRNA expression was not detected. HTLV-I viral RNA expression was detected only in one case in which IL-3 mRNA was expressed in both peripheral blood and lymph node cells and a relatively high proportion of leukemic cells expressed IL-2 receptor (p55, Tac). Thus, in the present study we could not find any correlation between cytokine expression and HTLV-I expression in peripheral blood fresh leukemic cells except in one unusual case.

References

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Citations

Nov 1, 1996·Journal of Clinical Immunology·T Uchiyama
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·C KawasakiY Niho
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·S TakemotoG Franchini
Oct 8, 1999·Leukemia & Lymphoma·Y Yamada, S Kamihira
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Jun 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P CarboneJay A Berzofsky
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·T UchiyamaA Imura
Sep 13, 2002·European Journal of Haematology·Hirofumi BabaShimeru Kamihira
Aug 1, 1995·European Journal of Haematology·N MoriS Eto
Mar 1, 1993·European Journal of Haematology·N MoriS Eto

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