PMID: 9548183Apr 21, 1998Paper

Expression of cytokine receptors in the placenta in term and preterm labour

Placenta
A SteinbornM Kaufmann

Abstract

Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues. In this study, cytokine receptor positive cells in frozen tissue sections of placentae (n=70) and fetal membranes (n=50) were identified by immunohistological staining with monoclonal antibodies specific for IL-6 receptor, TNF receptors I and II, and IL-1 receptor I. Both subunits of the IL-6 receptor (gp130 and gp80) as well as TNF receptors I and II were expressed by fetal endothelial cells within placental villi, while IL-1-receptor I was detected exclusively in stromal cells of the maternal decidua. The IL-1 receptor I and TNF receptors I and II were expressed in both uterine quiescence and labour, irrespective of gestational age. Immunoreactivity of the gp130 subunit of the IL-6 receptor was found also throughout pregnancy, while the appearance of the gp80 subunit correlated with the presence of term and preterm labour. In case of preterm labour, expression of the gp80 subunit was predominantly detected in the a...Continue Reading

References

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Citations

May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński
Nov 18, 1998·Current Opinion in Obstetrics & Gynecology·D S TorryJ A McIntyre
Feb 24, 2007·Journal of Endocrinological Investigation·N VitoratosG Creatsas
Sep 21, 2006·The Journal of Obstetrics and Gynaecology Research·Nicolaos VitoratosGeorge Creatsas
Feb 13, 2001·Placenta·J F DyeJ A Firth
Feb 3, 2011·American Journal of Obstetrics and Gynecology·Pooja MittalSonia S Hassan
Nov 16, 1999·American Journal of Obstetrics and Gynecology·E MaymonR Romero
Jun 30, 2000·Seminars in Cell & Developmental Biology·J S HuntT G Burnett
Sep 27, 2014·BioMed Research International·Silvija CviticUrsula Hiden
Feb 23, 2017·Journal of Pathology and Translational Medicine·Haidy El-AzzamyNandor Gabor Than
Oct 22, 2003·Reproductive Biomedicine Online·Rekha M RaoA Jagannadha Rao

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