Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection

Scientific Reports
Shuo-Chun WengDer-Cherng Tarng

Abstract

Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease. We prospectively investigated a cohort comprising 96 renal transplant recipients (RTRs) undergoing graft kidney biopsies. Computer-assisted quantitative immunohistochemical staining value of DcR3 in renal tubular epithelial cells (RTECs) was used to determine the predictive role of DcR3 in kidney disease progression. The primary end point was doubling of serum creatinine and/or graft failure. A multivariate Cox proportional hazards model was used to assess the risk of DcR3 expression in rejected kidney grafts toward the renal end point. In total, RTRs with kidney allograft rejection were evaluated and the median follow-up was 30.9 months. The greater expression of DcR3 immunoreactivity in RTECs was correlated with a higher rate of the histopathological concordance of acute T cell-mediated rejection. Compared with 65 non-progressors, 31 progressors had higher DcR3 expression (HDE) regardless of the traditional risk factors. Cox regression analysis showed HDE was significantly associated with the risk of renal end point with a hazard ratio of 3.19 (95% confidence interval, 1.40 to 7.27; P = 0.006) after adjusting for oth...Continue Reading

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Citations

Sep 7, 2016·Canadian Journal of Gastroenterology & Hepatology·Giorgos BamiasSpiros D Ladas
Jul 30, 2019·Journal of the Chinese Medical Association : JCMA·Shuo-Chun Weng, Der-Cherng Tarng

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Datasets Mentioned

BETA
AF104419

Methods Mentioned

BETA
biopsy
biopsies
transgenic
imaging
confocal microscopy
in vitro transcription

Software Mentioned

Pro Plus
SPSS
Statistical Package for the Social Sciences
Adobe Photoshop
Image
MedCalc

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