Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer.

Digestive Diseases and Sciences
Yue LiHuizhong Zhang

Abstract

Reversible N6-methyladenosine (m6A) modifications in messenger RNAs can be categorized under the field of "RNA epigenetics." However, the potential role of m6A-related genes in gastric cancer (GC) prognosis has not been systematically researched. This study was aimed at providing insights into the prognostic role of m6A-related gene expression, at both mRNA and protein levels. Kaplan-Meier (KM) plotter database and The Cancer Genome Atlas (TCGA) database were used to explore the prognostic significance of individual m6A-related genes in overall survival (OS) and progression-free survival at the mRNA level. For independent validation, the protein level of genes significantly associated with prognosis in both databases was further detected in 450 paired GC and corresponding adjacent non-tumor tissues using tissue microarray (TMA)-based immunohistochemistry (IHC). The relationship between the FTO and ALKBH1 expression and the clinicopathological characteristics was explored. Among nine m6A-related genes, aberrantly high mRNA expression of FTO and ALKBH1 was associated with poor OS in the KM and TCGA cohorts. However, the TMA-IHC indicated that protein expression of FTO and ALKBH1 was markedly downregulated in GC tissues. A lower p...Continue Reading

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Citations

Jun 11, 2020·RNA Biology·Sherif RashadKuniyasu Niizuma
May 15, 2020·Experimental & Molecular Medicine·Seung Hun Han, Junho Choe
Jul 10, 2020·Cellular and Molecular Life Sciences : CMLS·Baofang XuYongchun Zuo
Aug 8, 2020·Cancer Cell International·Guanqun YangNan Zhang
May 14, 2020·Molecular Cancer·Tianyi WangShaoqing Ju
Apr 25, 2019·International Journal of Molecular Medicine·Wei ZhuHaiwei Yang
Dec 21, 2020·Journal of Cellular and Molecular Medicine·Yangyang LeiXiaolin Wang
Jan 30, 2021·The FEBS Journal·Takeshi Chujo, Kazuhito Tomizawa
May 7, 2021·Cancer Communications·Shenghua DongHuilin Huang
May 29, 2021·Molecular Biology Reports·Ying Zhang, Caiyan Wang
Jul 12, 2021·Experimental Hematology & Oncology·Junchao HuangWendong Gu
Oct 1, 2021·Oncology Letters·Yang ZhouWeigan Shen
Jan 21, 2020·Molecular Therapy. Nucleic Acids·Lina LiuHong Fan
Nov 19, 2021·Journal of Medicinal Chemistry·Gemma S PerryEsther C Y Woon

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Methods Mentioned

BETA
surgical resection
RNAseq
PCR

Software Mentioned

GraphPad Prism
R
SPSS Statistics
KM plotter
KM
PostgreSQL
Affy Bioconductor
SPSS

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