Expression of dicer and its related miRNAs in the progression of prostate cancer

PloS One
Xiaojie BianDingwei Ye

Abstract

Dicer is aberrantly expressed in several types of malignancies. Cleaved by Dicer, the small noncoding microRNAs (miRNAs) are considered potential tools for the diagnosis and prognosis of cancer. This study investigated the expression of miRNAs thought to target Dicer. Expression of 1,205 human miRNAs and miRNA*s were examined in four patients with prostate cancer (PCa) by miRNA array in which the threshold was set as two-fold. Seventy-three miRNAs and miRNA*s were significantly down-regulated while 10 were up-regulated in PCa tissues compared with matched histologically normal glands. Of these, miR-29b-1, miR-200a, miR-370, and miR-31, which were the most down/up-regulated and closely potentially target to the Dicer 3' UTR, were investigated further. Tissues of primary tumors and matched normal prostate glands from 185 patients with PCa were collected for further investigation. Dicer mRNA levels were negatively correlated with miR-29b-1 (ρs = -0.177, p = 0.017), miR-200a (ρs = -0.489, p < 0.0001) and miR-31 (ρs = -0.314, p < 0.0001) expression. Compared with adjacent normal glands, PCa tissues showed significantly lower miR-200a and miR-31 expression levels. Furthermore, in metastatic PCa, the expression levels of miR-200a, miR...Continue Reading

References

Sep 17, 2004·Nature·Victor Ambros
Oct 31, 2006·The American Journal of Pathology·Simion ChioseaRajiv Dhir
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Feb 10, 2009·Nature Clinical Practice. Urology·William P HarrisBruce Montgomery
Jun 16, 2009·Cell·Scott ValastyanRobert A Weinberg
Sep 26, 2009·Endocrine-related Cancer·Valeria CoppolaDésirée Bonci
Jul 3, 2010·International Journal of Oncology·Lei HanChun-Sheng Kang
Jul 7, 2010·Cell·Graziano MartelloStefano Piccolo
Oct 5, 2010·Japanese Journal of Clinical Oncology·Mikio NamikiShigeo Horie
Nov 5, 2010·PloS One·Ramesh NarayananJames T Dalton
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Khalid Sossey-AlaouiEdward F Plow
Nov 22, 2011·Nature Medicine·Bogdan MateescuFatima Mechta-Grigoriou
Mar 31, 2012·RNA·Jr-Shiuan YangEric C Lai
Jul 24, 2012·Breast Cancer Research and Treatment·Sarkawt M KhoshnawAndrew R Green
Sep 29, 2012·Neoplasia : an International Journal for Oncology Research·Lina CekaiteRolf I Skotheim
Nov 8, 2012·Nature Reviews. Urology·Lara K BoydYong-Jie Lu
Nov 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Carolina FerrazMarkus Eszlinger
Mar 19, 2013·Journal of Clinical Bioinformatics·Rishabh KalaTrygve O Tollefsbol
Jul 16, 2014·Nature Reviews. Genetics·Jean Hausser, Mihaela Zavolan
Aug 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Jie BianDing-Wei Ye

❮ Previous
Next ❯

Citations

Jan 30, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Balraj Singh GillSanjeev Kumar
Jan 17, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Shweta DambalLarisa Nonn
Feb 1, 2017·Molecular and Cellular Endocrinology·Penn MuluhngwiCarolyn M Klinge
Oct 23, 2018·The Prostate·Ilknur SuerMustafa Ozen
Feb 28, 2020·Medicina·Vlad Cristian MunteanuIoan Coman
Sep 28, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Zhao WangYaqing Si
Mar 8, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anjan K PradhanPaul B Fisher

❮ Previous
Next ❯

Methods Mentioned

BETA
Feature Extraction
PCR
transfection

Software Mentioned

GeneSpring GX
Agilent Feature Extraction
TargetScan
SPSS

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis