Expression of Distal-less in molluscan eggs, embryos, and larvae

Evolution & Development
S E Lee, David K Jacobs

Abstract

Distal-less (Dll) is best known as a transcription factor involved with "limb patterning" in Drosophila melanogaster. Observations of both deuterostome and protostome phyla have led to the suggestion that some aspect of this gene's function in "appendage" or proximal-distal "outgrowth" development is conserved. Here we explore the possibility of other conserved roles operating earlier in development. We examine the expression of DLL protein during the early development of two molluscan classes, Polyplacophora (chiton) and Gastropoda (snail). Using an antibody approach, we find DLL expression in the oocytes of a chiton (Mopalia muscosa) and in the pregastrulae through early veliger larvae of a marine snail (Kelletia kelletii). We observe antibody localization in the oocyte, nuclear expression in all cells of the pregastrulae, and predominant expression in the ectoderm of postgastrulae and early veliger larvae. Comparison of our observations on spiralian taxa, thought to have conservative development with previous work, primarily on deuterostomes, suggests the possibility of an ancient role(s) for DLL in early development. Possible functions appear to include maternal and zygotic involvement in the establishment of embryonic pola...Continue Reading

References

Mar 1, 1992·Differentiation; Research in Biological Diversity·P DolléD Duboule
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M I MorassoT D Sargent
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SimeoneK Huebner
Apr 1, 1994·Mechanisms of Development·M L DirksenM Jamrich
Nov 1, 1994·The Journal of Experimental Zoology·K M WeissK Takashita
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W StockK M Weiss
Dec 15, 1996·Genomics·S NakamuraF H Ruddle
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·G PanganibanS B Carroll
Jul 10, 1997·Nature·T Lecuit, S M Cohen
May 1, 1994·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Lewis I HeldScott D Peters

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Citations

Apr 8, 2003·Developmental Biology·David M Parichy, Jessica M Turner
Aug 19, 2011·BMC Evolutionary Biology·Carmel McDougallDavid Ek Ferrier
Oct 27, 2011·PLoS Genetics·Matthias PechmannNikola-Michael Prpic
May 15, 2002·Evolution & Development·Christopher J LoweGregory A Wray
Jun 28, 2017·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hua ZhangMaoxian He
Nov 17, 2001·Evolution & Development·F R Schram, S Koenemann
Apr 30, 2017·BMC Biology·Bruno C VellutiniAndreas Hejnol
Apr 12, 2003·Development Genes and Evolution·Claus Nielsen, Pedro Martinez

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