PMID: 2493133Mar 1, 1989Paper

Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents

Mutation Research
M R VolkertL I Hajec

Abstract

Several alkylation-inducible genes have been identified by construction of Mu-d1 (Apr lac) fusions to genes whose expression is increased in response to alkylation treatment, but not UV treatment. We have examined the induction of 4 different alkylation-inducible genes by treatment with a variety of methylating and ethylating agents, and a propylating agent. We have compared the induction of the alkylation-inducible genes with the induction of the sulA gene, which is a component of the SOS response to DNA damage. We find that the Ada-regulated adaptive response genes (ada-alkB, alkA and aidB) are induced primarily in response to methylation treatment. The ada-independent aidC gene is induced upon treatment with agents that alkylate predominantly by SN1 nucleophilic attack. aidC induction occurs only when cells are not aerated during treatment. The SOS response, as indicated by sulA induction, is strongly induced by all types of alkylating agents used.

References

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Citations

Nov 15, 1994·Molecular & General Genetics : MGG·E Grzesiuk, C Janion
Oct 1, 1993·Mutation Research·E Grzesiuk, C Janion
Apr 3, 2001·Current Opinion in Microbiology·M R Volkert, P Landini
Jan 25, 2011·Microbial Biotechnology·Alva BiranShimshon Belkin
Sep 22, 2007·FEMS Microbiology Reviews·Ivan ErillJordi Barbé
Mar 4, 2014·Chemical Reviews·Guanqun ZhengChuan He
Oct 16, 1999·Periodontology 2000·S C HoltC A Genco
Jun 2, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Dong Xu, Jean-Charles Côté
Jan 1, 1990·Environmental and Molecular Mutagenesis·M J HorsfallB W Glickman
Jan 1, 1990·Environmental and Molecular Mutagenesis·J Tsimis, D B Yarosh
Sep 22, 2005·The Journal of Biological Chemistry·Dong-Hyun LeeTimothy R O'Connor
Feb 1, 2013·EcoSal Plus·Sophie CouvéMurat Saparbaev
Sep 17, 2013·ACS Synthetic Biology·Felix MoserChristopher A Voigt
Oct 23, 2018·Biochemistry·Roopa ThaparJohn A Tainer
Jul 26, 2011·Archives of Biochemistry and Biophysics·Scott B MulrooneyRobert P Hausinger

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