Expression of doublecortin in tumours of the central and peripheral nervous system and in human non-neuronal tissues

Acta Neuropathologica
Christian BernreutherChristian Hagel

Abstract

Doublecortin is a microtubule-associated phosphoprotein involved in neuronal migration and differentiation expressed in migrating neuroblasts in the central nervous system. We systematically analysed doublecortin expression in 179 tumours of the central and 65 tumours of peripheral nervous system as well as in 74 different non-neuronal tissues to evaluate the specificity of doublecortin as a marker for neuronal differentiation in glioneuronal tumours. Glioneuronal tumours and oligodendrogliomas grade II and III uniformly showed a high intensity and frequency of doublecortin staining, whereas intermediate doublecortin expression was observed in astrocytic tumours of grade II-IV. In pilocytic astrocytomas and ependymomas only scattered doublecortin positive cells were detected. In the peripheral nervous system, doublecortin expression was found in neurofibroma but was absent in schwannoma. Double staining of tumour tissue revealed co-expression of doublecortin and neurofilament in cells of gangliocytomas and gangliogliomas and co-expression of doublecortin with S100 protein or GFAP in glial tumours, respectively. In a tissue array comprised of 74 different normal non-neuronal human tissues, doublecortin expression was demonstrate...Continue Reading

References

Oct 17, 1998·Neuropathology and Applied Neurobiology·S B WhartonJ R Anderson
Aug 30, 2002·Acta Neuropathologica·Masashi MizuguchiSachio Takashima
Jun 26, 2003·Archives of Pathology & Laboratory Medicine·B K Kleinschmidt-DeMastersKenneth R Shroyer
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Jan 27, 2004·Neuron·Joseph LoTurco
Jul 13, 2004·Brain Research. Developmental Brain Research·Andréanne Bédard, André Parent
Jan 19, 2005·The European Journal of Neuroscience·Sebastien Couillard-DespresLudwig Aigner
Feb 17, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Silvestre OltraVictoria Castel
Apr 22, 2005·Acta Neuropathologica·Matthias PreusserJohannes A Hainfellner
May 19, 2005·Cancer Research·Jeremy N RichMike West
Oct 1, 2005·Acta Neuropathologica·Marie-Claire DaouAlonzo H Ross

❮ Previous
Next ❯

Citations

Aug 29, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristina EvangelistiSilvia Anna Ciafrè

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
Silvestre OltraVictoria Castel
Neoplasia : an International Journal for Oncology Research
Jeanette D WaltonRobert A Ross
© 2021 Meta ULC. All rights reserved