PMID: 8944636Nov 11, 1996Paper

Expression of Drosophila melanogaster P-glycoproteins is associated with ATP channel activity

The American Journal of Physiology
I BoschH F Cantiello

Abstract

Two distinct Drosophila melanogaster P-glycoprotein (Pgp) gene homologues of different chromosomal origin, MDR49 and MDR65, have been previously identified (38). Most Pgps are implicated in the development of the multidrug-resistance phenotype. Despite intense efforts to identify the molecular mechanism(s) associated with Pgp function, the endogenous substrate(s) of these transport molecules is largely unknown. Recent studies from our laboratory indicate that a murine Pgp homologue (E. H. Abraham, A. G. Prat, L. Gerweck, T. Seneveratne, R. J. Arceci, R. Kramer, G. Guidotti, and H. F. Cantiello. Proc. Natl. Acad. Sci. USA 90: 312-316, 1993) and a related protein, the cystic fibrosis transmembrane conductance regulator (CFTR; I. L. Reisin, A. Prat, E. H. Abraham, J. F. Amara, R. J. Gregory, D. A. Ausiello, and H. F. Cantiello. J. Biol. Chem. 269: 20584-20591, 1994), are novel ATP-permeable ion channels. The common feature of these two proteins is the conserved ATP-binding cassettes (ABC); thus molecules structurally linked to the ABC transporter family may be also functionally associated with ATP channel activity. In this study, MDR65 and MDR49 Pgps were functionally expressed in Sf9 cells, and patch-clamp techniques were applied...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M J StuttsR C Boucher
Aug 1, 1991·Molecular and Cellular Biology·C T WuJ M Croop
Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M M Gottesman, I Pastan
Jan 1, 1989·Annual Review of Biochemistry·J A Endicott, V Ling
Dec 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P F JurankaV Ling
Jan 1, 1989·Advances in Cancer Research·A M van der Bliek, P Borst
Dec 30, 1986·Biochemical and Biophysical Research Communications·K UedaJ R Riordan
May 1, 1988·The Journal of Clinical Investigation·J M CroopD E Housman
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E H AbrahamH F Cantiello

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Citations

Jul 18, 2000·American Journal of Physiology. Cell Physiology·A S LaderH F Cantiello
Aug 15, 2000·Journal of Cellular Physiology·K Lange
Jul 10, 2001·American Journal of Physiology. Cell Physiology·K Lange, J Gartzke
Apr 15, 2000·The Journal of Biological Chemistry·E BodasC Solsona
Aug 29, 2013·Insect Molecular Biology·J Figueira-MansurM F Moreira
Oct 14, 2016·Journal of Applied Toxicology : JAT·Adélaïde LereboursJean-Paul Bourdineaud
Apr 8, 1998·The American Journal of Physiology·H F CantielloD A Ausiello
Mar 26, 2004·The Japanese Journal of Physiology·Ravshan Z Sabirov, Yasunobu Okada
Jul 5, 2003·Physiological Reviews·Julian T Dow, Shireen A Davies
Dec 31, 1997·The American Journal of Physiology·T SchlenkerJ G Fitz
Apr 12, 2008·Purinergic Signalling·Ravshan Z Sabirov, Yasunobu Okada
Sep 6, 2000·Clinical Physiology·A S LaderH F Cantiello
Sep 4, 2004·Biophysical Journal·Ravshan Z Sabirov, Yasunobu Okada

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