Expression of dyskinetic movements and turning behaviour in subchronic L-DOPA 6-hydroxydopamine-treated rats is influenced by the testing environment

Behavioural Brain Research
Annalisa PinnaMicaela Morelli

Abstract

Sensitisation in contralateral turning behaviour and induction of abnormal involuntary movements (AIMs) after subchronic intermittent L-DOPA were compared for their predictive validity as model of parkinsonian dyskinetic movements. L-DOPA treatment produced sensitisation in turning behaviour in 6-hydroxydopamine-lesioned rats, when animals were evaluated in hemispherical bowls but not in cages. In contrast, sensitisation in AIMs was obtained both in hemispherical bowls and cages. Results provide evidence that the choice of the environment used in evaluation of AIMs and turning behaviour is of crucial importance.

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Citations

Aug 31, 2006·Behavioural Pharmacology·Anna R CartaMicaela Morelli
Jul 4, 2012·Parkinson's Disease·Micaela MorelliRobert A Hauser
Sep 11, 2007·Progress in Neurobiology·Micaela MorelliMichael A Schwarzschild
Apr 30, 2014·Journal of Neurochemistry·Rolf HeumannMicaela Morelli
Oct 13, 2006·Trends in Neurosciences·Michael A SchwarzschildMicaela Morelli
Oct 18, 2012·Neurobiology of Disease·Ludivine S BregerEmma L Lane
Apr 23, 2008·Current Protocols in Neuroscience·M Angela Cenci, Martin Lundblad
Nov 5, 2019·Frontiers in Neurology·Qiwei PengYan Xu

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