PMID: 15365368Sep 15, 2004Paper

Expression of e-cadherin and beta-catenin in cutaneous squamous cell carcinoma and its precursors

The American Journal of Dermatopathology
Anna LyakhovitskyMonika Huszar

Abstract

The E-cadherin-beta-catenin complex regulates the architectural integrity of epithelia by mediating intercellular adhesion. Down-regulation of its expression may contribute to invasion and metastatic behavior of carcinoma cells. Several studies demonstrated an abnormal expression of E-cadherin, beta-catenin, or both in various carcinomas, including non-melanoma skin cancer. The aim of the present study was to investigate the involvement of E-cadherin-catenin adhesion system in the progression of human cutaneous squamous cell carcinoma (SCC). For that purpose, sections from normal skin, skin showing solar elastosis (SE), solar keratosis (SK), and SCC were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed using a semi-quantitative method in which pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining were evaluated. Normal skin and skin showing mild and moderate solar elastosis strongly expressed membranous E-cadherin and beta-catenin. E-cadherin expression was progressively reduced in the epidermis of skin with severe solar elastosis through solar keratosis to SCC. The same phenomenon was observed for beta-catenin starting f...Continue Reading

References

Oct 1, 1992·Current Opinion in Cell Biology·S TsukitaS Yonemura
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkaS Hirano
Dec 1, 1990·Differentiation; Research in Biological Diversity·M FogelB Czernobilsky
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Nov 1, 1994·The Journal of Dermatology·F FurukawaS Imamura
Jan 1, 1994·British Journal of Cancer·A PizarroC Gamallo
Apr 15, 1996·Cancer·H ShiozakiM Monden
Jan 1, 1996·The British Journal of Dermatology·L C FullerD M Macdonald
Apr 1, 1996·Melanoma Research·E H DanenG N van Muijen
Feb 1, 1996·The Journal of Dermatology·H TadaT Shirai
Aug 15, 1997·Microscopy Research and Technique·F FurukawaM Takigawa
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B M GhadimiP M Schlag
Nov 5, 1999·Molecular Cell Biology Research Communications : MCBRC·F NolletF van Roy
Dec 22, 1999·Journal of the American Academy of Dermatology·C J Cockerell
Feb 5, 2000·Journal of Cutaneous Pathology·H TadaT Muramatsu
Jun 30, 2000·The Journal of Dermatology·S KosekiS Kondo
Oct 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melissa C ChilesBruce R Smoller

❮ Previous
Next ❯

Citations

Nov 2, 2005·Histochemistry and Cell Biology·Karel SmetanaHans Joachim Gabius
Feb 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Agnieszka Kobielak, Elaine Fuchs
May 21, 2013·Actas dermo-sifiliográficas·A Martorell-CalatayudC Guillén Barona
Feb 15, 2012·The Science of the Total Environment·Jerome NriaguDebashis Chatterjee
Oct 26, 2010·Annals of Diagnostic Pathology·Juliana L SchusselMarília Trierveiler Martins
Apr 21, 2009·The Journal of Surgical Research·Vanessa JensenRobert S Krouse
May 18, 2012·The Journal of Investigative Dermatology·Emmanouil KyriakakisThérèse J Resink
Jul 21, 2011·Journal of Skin Cancer·de Lima Vazquez ViniciusAndré Lopes Carvalho
Feb 14, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·S BaumI Bank
Jan 12, 2007·Journal of Cutaneous Pathology·Houjun LiuYoichi Moroi
Aug 20, 2011·Molecular Carcinogenesis·Kimberly A SmithJill C Pelling
Apr 27, 2011·Journal of Cutaneous Pathology·Myung ImJeung H Lee
Nov 19, 2014·International Journal of Cancer. Journal International Du Cancer·Katrin SobelPetra Boukamp
May 25, 2016·Pathology, Research and Practice·Onder BozdoganIsik G Yulug
Jul 1, 2016·American Journal of Clinical Dermatology·Kyle A BurtonAmor Khachemoune
May 26, 2009·Brazilian Dental Journal·Maria Carmen Fontoura Nogueira da CruzLeão Pereira Pinto
Mar 27, 2007·Journal of Cutaneous Pathology·Tarcília Aparecida da SilvaFlorêncio Figueiredo Cavalcante Neto
Jul 8, 2020·International Journal of Molecular Sciences·Montserrat ReyesVicente A Torres
Jan 15, 2020·Analytical Cellular Pathology (Amsterdam)·Anastasia HodorogeaAlice Brinzea
Jul 13, 2019·The British Journal of Dermatology·A BakshiC A Elmets

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The New England Journal of Medicine
M Alam, D Ratner
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Melissa C ChilesB R Smoller
The British Journal of Dermatology
M El-BahrawyM Fallowfield
© 2021 Meta ULC. All rights reserved