PMID: 7538975May 16, 1995Paper

Expression of E-selectin on endothelial cells of small veins in human colorectal cancer

International Journal of Cancer. Journal International Du Cancer
C YeH Takagi

Abstract

E-selectin is an adhesion molecule of endothelial cells that binds to cancer cells mediated by sialyl Lewis A (sLea) or sialyl Lewis X (sLe(x)). It is suspected to be involved in hematogenous metastasis of tumors. Therefore, it is worth examining E-selectin expression in human colorectal cancer and its hepatic metastasis. In the present study, E-selectin was clearly revealed on the endothelial cells of small vessels adjacent to cancer nests both in primary and in metastatic nests in immunohistochemistry. In these tissues, E-selectin was observed on the endothelial cells lining the lumen of small vessels. Its expression adjacent to cancer nests appears to be induced through some stimuli by cancer cells, since its degree of expression is inversely correlated to the distance of the blood vessels from the cancer nests (p < 0.001). Endothelial cells adjacent to the metastatic lesion expressed E-selectin more extensively than those adjacent to the primary foci. This is also in line with the finding on serum E-selectin levels which were significantly elevated in the metastatic group as compared with the non-metastatic group. The serum E-selectin level may provide useful information in the diagnosis for hepatic metastasis of colorectal...Continue Reading

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·J R MerwinM Lynch
Sep 16, 1992·Biochemical and Biophysical Research Communications·R PigottA J Gearing
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Sep 16, 1991·Biochemical and Biophysical Research Communications·A TakadaR Kannagi
Oct 1, 1990·Transplantation·J S Pober, R S Cotran
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D SpriggsD W Kufe

❮ Previous
Next ❯

Citations

Feb 24, 2000·The Journal of Pathology·F W OrrD M Nance
Aug 22, 1996·International Journal of Cancer. Journal International Du Cancer·T KishimotoT Yoshiki
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·P BrodtB A Wolitzky
Jun 1, 1996·Cancer Metastasis Reviews·R K JainR J Melder
Jan 9, 2008·Cancer Metastasis Reviews·Isaac P Witz
Sep 25, 2007·Clinical & Experimental Metastasis·Stéphanie GoutJacques Huot
Jul 10, 2003·The Journal of Surgical Research·Makoto YoshidaKuniyoshi Tanaka
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D AlexiouC Tsigris
Jul 20, 2002·Bioorganic & Medicinal Chemistry Letters·Wenqian YangBrent Weston
May 20, 2006·Neurosurgical Focus·Christiana CharalambousFlorence M Hofman
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shirin AzizidoostNajmaldin Saki
May 15, 2007·Microvascular Research·Megumi IiizumiKounosuke Watabe
Dec 23, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qiang ZuoWangjun Liao
Jul 25, 2009·Journal of Cellular and Molecular Medicine·Konstantinos A PaschosNigel C Bird
Jun 8, 2002·Biochemical and Biophysical Research Communications·A M FlugyR Alessandro
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Steven R BarthelCharles J Dimitroff
Jul 20, 2002·Experimental and Molecular Pathology·N SimiantonakiC J Kirkpatrick
Oct 25, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Aleksandra KornilukVioletta Dymicka-Piekarska
Nov 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amina MohammadalipourDavid F J Tees
Sep 24, 2004·The British Journal of Surgery·S-M Sheen-ChenW-J Chen
Dec 12, 2012·Small·Chang-Sheng ChenXian-Zheng Zhang
Jan 11, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Charlotte F J M PeetersRobert M W de Waal
Mar 1, 2002·British Journal of Cancer·D Eaton, R E Hawkins
May 1, 1996·The British Journal of Surgery·M D Menger, B Vollmar
Mar 21, 2007·International Journal of Cancer. Journal International Du Cancer·Riccardo AlessandroGiacomo De Leo
May 11, 2004·Cancer Science·Reiji KannagiNaoko Kimura
May 19, 2020·The Journal of International Medical Research·Hilal Kiziltunc Ozmen, Melih Simsek
Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Er-Yong LaiYun-Feng Li
May 13, 1999·International Journal of Experimental Pathology·A W GriffioenH F Hillen
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·H ItoR Kannagi
Jan 28, 2006·World Journal of Gastroenterology : WJG·Masanao KurataNobuhiro Ohkohchi
Sep 29, 2020·Frontiers in Physiology·Alex L WilkinsonShishir Shetty
Jul 25, 2020·Nature Communications·Myriam L R Haltalli, Cristina Lo Celso
Sep 14, 1999·The American Journal of Physiology·R R LangleyD N Granger
Sep 23, 2008·Bioconjugate Chemistry·Xavier BanquySuzanne Giasson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.