Abstract
The E2F family of transcription factors plays a key role in the control of cellular proliferation and apoptosis. Some family members act as oncogenes and others act as tumour suppressor genes (TSGs), behaviour which appears to be tissue-specific. E2F-4 is a member of the E2F family, located at chromosome band 16q22.1, that shows frequent deletion in breast cancer, suggesting that it may function as a TSG in breast carcinogenesis. In the present study, the expression of E2F-4 was assessed immunohistochemically on paraffin wax sections from 265 breast carcinomas and expression was compared with both clinicopathological variables and disease outcome in an attempt to identify its possible role as a TSG and to assess its prognostic value, if any, in breast cancer. E2F-4 protein expression was detected in the nuclei and in the cytoplasm of normal and malignant breast epithelial cells. In the malignant tissues, no significant loss or decrease of expression was seen in association with any specific tumour type. There was a correlation between increased nuclear expression of E2F-4 and indicators of poor prognosis including larger tumour size (p = 0.000), grade 3 lesions (p = 0.033), lymph node stage (p = 0.037), and poorer Nottingham pr...Continue Reading
Citations
Oct 24, 2009·Nature Reviews. Cancer·Hui-Zi ChenGustavo Leone
Apr 20, 2006·BMC Cancer·Jane FridlyandDonna G Albertson
Jan 1, 2009·BMC Cancer·Mads ThomassenTorben A Kruse
May 18, 2011·BMC Medical Genomics·Siew Hong LamSinnakaruppan Mathavan
Jun 8, 2013·World Journal of Gastroenterology : WJG·Athanasios Xanthoulis, Dina G Tiniakos
Mar 1, 2016·Oncogene·J JohnsonR Bernards
Mar 24, 2010·Seminars in Diagnostic Pathology·Peter T SimpsonSunil R Lakhani
Jun 30, 2009·Journal of Cellular Physiology·Hugo GarneauNathalie Rivard
Mar 5, 2011·Molecular Carcinogenesis·Rune ThomsenAnders L Nielsen
Oct 11, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P K Tsantoulis, V G Gorgoulis
Mar 14, 2013·Journal of Pediatric Surgery·Keiichi UchidaMasato Kusunoki
Oct 11, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·M S WeissL D Shea
Mar 7, 2006·Genes, Chromosomes & Cancer·Emad A RakhaIan O Ellis
Jul 12, 2020·Cells·Masanori OshiKazuaki Takabe
Apr 26, 2016·Oncology Reports·Ying WuJi-Feng Feng
Oct 9, 2013·International Journal of Oncology·Marie-Christine PaquinNathalie Rivard
Dec 17, 2016·Cancer Biomarkers : Section a of Disease Markers·Flávia S DonairesElza T Sakamoto-Hojo
May 6, 2019·Nature Reviews. Cancer·Lindsey N Kent, Gustavo Leone
Dec 17, 2005·Cancer Research·Ranjit S BindraPeter M Glazer
Feb 25, 2020·Pathology, Research and Practice·Young-Sik KimJung-Woo Choi
Jul 24, 2021·International Journal of General Medicine·Dingtao HuFang Wang