Expression of early growth response-1 in colorectal cancer and its relation to tumor cell proliferation and apoptosis

Oncology Reports
Dae-Seong MyungYoung-Eun Joo

Abstract

Early growth response-1 (Egr-1) is implicated in the regulation of cell growth, proliferation, differentiation and apoptosis. Egr-1 is considered tobe either a tumor-suppressor or tumor-promoter, depending on the cell type and environment. The aim of the present study was to evaluate the expression of Egr-1 in colorectal cancer and its correlation with tumor cell proliferation, apoptosis and clinicopathological features. The expression of Egr-1 in colorectal cancer tissues was investigated by reverse transcription-polymerase chain reaction (RT-PCR), western blotting and immunohistochemistry. Apoptosis was detected by terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL), and cellular proliferative activity was evaluated by immunohistochemical staining with the Ki-67 antibody. Egr-1 expression was significantly elevated in colorectal cancer tissues, when compared to that in the paired normal mucosa at the mRNA and protein levels. In addition, Egr-1 expression was significantly increased in the metastatic lymph node tissues, when compared to that in the non‑metastatic lymph node tissues at the protein level. The mean Ki-67 labeling index (KI) and apoptotic index (AI) value...Continue Reading

References

Apr 5, 2016·Nature Communications·Sherry Y WuAnil K Sood
Jul 8, 2017·Scientific Reports·Ying WangHaiyan Hu
Jun 11, 2020·Scientific Reports·Arnon Møldrup KnudsenBjarne Winther Kristensen

Citations

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Jan 1, 1995·Progress in Nucleic Acid Research and Molecular Biology·A Gashler, V P Sukhatme
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·R P HuangE Adamson
Apr 4, 2000·Molecular Carcinogenesis·P K RiggsJ DiGiovanni
Nov 6, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Frederick L Kiechle, Xinbo Zhang
Jul 2, 2003·Seminars in Arthritis and Rheumatism·Duane R Schultz, William J Harrington
Jan 10, 2006·Diseases of the Colon and Rectum·Marja HilskaPeter J Roberts
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Oct 2, 2009·Future Oncology·Delphine Gitenay, Véronique T Baron
Jan 21, 2010·British Journal of Cancer·D MahalingamE Szegezdi
May 4, 2011·International Journal of Colorectal Disease·George E TheodoropoulosNikolaos Nikiteas
Aug 23, 2011·Clinical Colorectal Cancer·Jonathan M HernandezDavid Shibata
May 9, 2012·Methods in Molecular Biology·Kateryna KyrylkovaChrissa Kioussi
Sep 25, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W L HeW H Zhan

Related Concepts

Immunohistochemistry
Plasma Cell Labeling Index
Apoptosis, Intrinsic Pathway
Continuance of Life
Western Blotting
Neoplasms
Promoter
DNA Nucleotidylexotransferase
Colorectal Neoplasms
Secondary Malignant Neoplasm of Lymph Node

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