Expression of early growth response-1 in colorectal cancer and its relation to tumor cell proliferation and apoptosis

Oncology Reports
Dae-Seong MyungYoung-Eun Joo


Early growth response-1 (Egr-1) is implicated in the regulation of cell growth, proliferation, differentiation and apoptosis. Egr-1 is considered tobe either a tumor-suppressor or tumor-promoter, depending on the cell type and environment. The aim of the present study was to evaluate the expression of Egr-1 in colorectal cancer and its correlation with tumor cell proliferation, apoptosis and clinicopathological features. The expression of Egr-1 in colorectal cancer tissues was investigated by reverse transcription-polymerase chain reaction (RT-PCR), western blotting and immunohistochemistry. Apoptosis was detected by terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL), and cellular proliferative activity was evaluated by immunohistochemical staining with the Ki-67 antibody. Egr-1 expression was significantly elevated in colorectal cancer tissues, when compared to that in the paired normal mucosa at the mRNA and protein levels. In addition, Egr-1 expression was significantly increased in the metastatic lymph node tissues, when compared to that in the non‑metastatic lymph node tissues at the protein level. The mean Ki-67 labeling index (KI) and apoptotic index (AI) value...Continue Reading


Apr 5, 2016·Nature Communications·Sherry Y WuAnil K Sood
Jul 8, 2017·Scientific Reports·Ying WangHaiyan Hu
Jun 11, 2020·Scientific Reports·Arnon Møldrup KnudsenBjarne Winther Kristensen


Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P LemaireP Charnay
Jan 1, 1995·Progress in Nucleic Acid Research and Molecular Biology·A Gashler, V P Sukhatme
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·R P HuangE Adamson
Apr 4, 2000·Molecular Carcinogenesis·P K RiggsJ DiGiovanni
Nov 6, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Frederick L Kiechle, Xinbo Zhang
Jul 2, 2003·Seminars in Arthritis and Rheumatism·Duane R Schultz, William J Harrington
Jan 10, 2006·Diseases of the Colon and Rectum·Marja HilskaPeter J Roberts
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Oct 2, 2009·Future Oncology·Delphine Gitenay, Véronique T Baron
Jan 21, 2010·British Journal of Cancer·D MahalingamE Szegezdi
May 4, 2011·International Journal of Colorectal Disease·George E TheodoropoulosNikolaos Nikiteas
Aug 23, 2011·Clinical Colorectal Cancer·Jonathan M HernandezDavid Shibata
May 9, 2012·Methods in Molecular Biology·Kateryna KyrylkovaChrissa Kioussi
Sep 25, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W L HeW H Zhan

Related Concepts

Plasma Cell Labeling Index
Apoptosis, Intrinsic Pathway
Continuance of Life
Western Blotting
DNA Nucleotidylexotransferase
Colorectal Neoplasms
Secondary Malignant Neoplasm of Lymph Node

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.