Expression of endothelial monocyte-activating polypeptide II in the rat dental follicle and its potential role in tooth eruption.

European Journal of Oral Sciences
Dawen Liu, G E Wise

Abstract

Endothelial monocyte-activating polypeptide II (EMAP-II) is an inflammatory cytokine with chemotactic activity. Because the dental follicle (DF) recruits mononuclear cells (osteoclast precursors) to promote the osteoclastogenesis needed for tooth eruption, it was the aim of this study to determine if EMAP-II contributes to this recruitment. Using a DNA microarray, EMAP-II was found to be highly expressed in vivo in the DFs of day 1 to day 11 postnatal rats, with its expression elevated on days 1 and 3. Use of a short interfering RNA (siRNA) to knock down EMAP-II expression resulted in a reduction in the expression of colony-stimulating factor-1 (CSF-1) and monocyte chemoattractant protein-1 (MCP-1) in the DF cells. Addition of EMAP-II protein to the DF cells partially restored the expression of CSF-1 and MCP-1. In chemotaxis assays using either conditioned medium of the DF cells with anti-(EMAP-II) immunoglobulin G added or conditioned medium of DF cells with EMAP-II knocked down by siRNA, migration indexes of bone marrow mononuclear cells were significantly reduced. These results suggest that EMAP-II is another chemotactic molecule in the dental follicle involved in the recruitment of mononuclear cells, and that EMAP-II may ex...Continue Reading

References

Mar 1, 1992·Cell and Tissue Research·G E WiseW Fan
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·U E KniesM Clauss
Feb 24, 2001·Journal of Dental Research·G E WiseQ Zhang
Mar 10, 2001·Apoptosis : an International Journal on Programmed Cell Death·U E KniesM Clauss
Jun 6, 2003·The Journal of Allergy and Clinical Immunology·Santa Jeremy OnoMasako Toda
Nov 1, 2003·Journal of Neurotrauma·Christian-Andreas MuellerJan M Schwab
Aug 21, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Christian WeberAlma Zernecke
Dec 28, 2004·Nature Biotechnology·Dong-Ho KimJohn J Rossi
Jul 7, 2005·Journal of Clinical Periodontology·Gülnur EmingilAfig Berdeli
Aug 20, 2005·Journal of Dental Research·G E WiseF Pan
Oct 6, 2005·European Journal of Oral Sciences·D LiuG E Wise
Mar 30, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·W Shane JourneayB Singh
Nov 22, 2007·Cardiovascular Research·Thomas G NührenbergDietlind Zohlnhöfer

❮ Previous
Next ❯

Citations

Jul 14, 2011·Physiological Genomics·Angela S PecheninoA A Knowlton
Feb 9, 2012·Connective Tissue Research·Dawen LiuGary E Wise
May 8, 2009·Orthodontics & Craniofacial Research·G E Wise
Jul 29, 2010·European Journal of Oral Sciences·Dawen LiuGary E Wise
Apr 5, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·H I YooS H Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.