Expression of endothelin-A-receptor predicts unfavourable response to neoadjuvant chemotherapy in locally advanced breast cancer

British Journal of Cancer
Pia WülfingL Kiesel

Abstract

Endothelin-1 (ET-1) and its receptors (ETAR and ETBR), referred to as the endothelin (ET) axis, are overexpressed in breast carcinomas and appear to influence tumour growth and progression. The objective of this study was to determine the effect of expression of the ET axis in breast carcinomas on response to cytotoxic chemotherapy. The study included 44 patients with locally advanced breast cancer participating in a prospective phase III study evaluating high-dose neoadjuvant chemotherapy of epirubicin and cyclophosphamide. Expression of ET-1, ETAR and ETBR was determined by semiquantitative immunohistochemical analysis of breast cancer tissue from prechemotherapy tru-cut biopsies. Immunohistochemical staining was positive for ET-1 in 61.5%, for ETAR in 35% and for ETBR in 35.9% of breast carcinomas. Pathological response to chemotherapy was significantly decreased in ETAR-positive patients (P=0.002). In total, 50% of ETAR-positive patients as compared to 7.7% of ETAR-negative patients attained pathologically 'no change'. Logistic regression confirmed ETAR as an independent predictive marker for pathological response (P=0.009). These data indicate that increased expression of ETAR in breast carcinomas is associated with resist...Continue Reading

References

Mar 1, 1977·British Journal of Cancer·J L HaywardR D Rubens
Sep 1, 1991·The Journal of Clinical Investigation·S KourembanasD V Faller
Aug 10, 1995·The New England Journal of Medicine·E R Levin
Oct 1, 1994·Geburtshilfe und Frauenheilkunde·H P SinnH F Otto
Jan 1, 1995·Surgical Oncology·K Kojima, Z Nihei
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherN V Dimitrov
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherH D Bear
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·L P EberlL Juillerat-Jeanneret
Nov 14, 2000·The American Journal of Pathology·D SalaniA Bagnato
Nov 15, 2000·Journal of Cardiovascular Pharmacology·H AliI Taylor
Nov 15, 2000·Journal of Cardiovascular Pharmacology·E L Bek, M A McMillen
Nov 15, 2000·Journal of Cardiovascular Pharmacology·L P EberlL Juillerat-Jeanneret
Feb 4, 2003·Nature Reviews. Cancer·Joel NelsonPerry Nisen
Mar 1, 2003·British Journal of Cancer·K GrantI Taylor
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·A Bagnato, K J Catt

❮ Previous
Next ❯

Citations

Jul 12, 2013·ISRN Oncology·Deimante TamkusNikolay V Dimitrov
Oct 19, 2010·Journal of Oncology·Adhemar Longatto FilhoFernando C Schmitt
Oct 13, 2006·Cancer Science·Hai-Qiang MaiMing-Huang Hong
Dec 27, 2005·Expert Review of Anticancer Therapy·Edwin HerrmannChristian Wülfing
Dec 6, 2018·International Journal of Molecular Sciences·Rosamaria LappanoMarcello Maggiolini
May 1, 2007·Breast Cancer Research and Treatment·M SmollichP Wülfing
Aug 19, 2007·European Journal of Gastroenterology & Hepatology·Moinuddin M HooseinMarilena Loizidou
Dec 5, 2009·International Journal of Cancer. Journal International Du Cancer·Jeanett FischgräbePia Wülfing
Mar 1, 2005·Oncogene·Isabelle M BerquinStephen P Ethier
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ander UrruticoecheaMitch Dowsett
Mar 15, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vasileios KallesAntonia Gounaris
Apr 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yue-Feng WenHai-Qiang Mai
Apr 10, 2007·Bioconjugate Chemistry·Carsten HöltkeChristoph Bremer

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
surgical resection
biopsies
xenograft

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Pia WülfingL Kiesel
Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
S RotondoF Staerman
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Zhi-gang ChenXue Yu
© 2022 Meta ULC. All rights reserved