Expression of endothelin-B receptors by glia in vivo is increased after CNS injury in rats, rabbits, and humans

Experimental Neurology
S D RogersP W Mantyh

Abstract

Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat and in vitro in cultures of astrocytes, microglia, or oligodendrocytes. Additionally, we examined the expression of ET receptors in the human optic nerve. Moderate levels of ET(B) receptors were identified in the rabbit and rat forebrain, whereas in the normal rabbit, rat, and human optic nerves a low density of ET(B) receptors was observed, mainly in association with glial fibrillary acidic protein + (GFAP+) astrocytes. After unilateral optic nerve transection, or damage to the retina, the density of glial ET(B) receptors in the optic nerve is significantly increased in all species examined. Thus, at 7 days posttransection there is a significant increase in ET(B) receptors, and by 90 days posttransection the density of ET(B) receptors in the rabbit or rat optic nerve was among the highest of any area in the central nervous system (CNS). Primary cultures of astrocytes or microglia, but not oligodendrocytes, expres...Continue Reading

References

Feb 1, 1992·Journal of Neurochemistry·E R LevinA Pedram
Jul 15, 1992·Biochemical and Biophysical Research Communications·H HamaK Goto
Sep 1, 1992·Journal of Neurochemistry·M L Simmons, S Murphy
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Jun 1, 1990·Journal of Neurochemistry·R MarsaultC Frelin
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P W MantyhS R Vigna
Jan 1, 1981·Journal of Immunological Methods·G D Johnson, G M Nogueira Araujo
Nov 1, 1993·Neuroscience Research·Y Nomura, Y Kitamura
Nov 1, 1994·Journal of the Neurological Sciences·K C MaW W Zhang
Apr 1, 1993·The Journal of Clinical Investigation·Y HirataF Marumo
Sep 1, 1994·Archives of Ophthalmology·M W MacCumber, S A D'Anna
Jan 17, 1994·Neuroscience Letters·K MaieseL Boccone
Sep 1, 1993·Journal of Neurochemistry·J A de JuanR Fernandez-Durango
Jan 1, 1993·Journal of Neurochemistry·R G LadenheimP O Couraud
Mar 1, 1993·Peptides·B BattistiniP Sirois

❮ Previous
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Citations

Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana GadeaVittorio Gallo
Jun 3, 2008·Canadian Journal of Physiology and Pharmacology·Raghu R KrishnamoorthyThomas Yorio
May 26, 2005·Brain Research. Brain Research Reviews·Lyle W Ostrow, Frederick Sachs
Mar 21, 2007·Molecular and Cellular Neurosciences·Maciej FigielJürgen Engele
Nov 3, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ganesh PrasannaThomas Yorio
May 4, 2004·Journal of Chemical Neuroanatomy·V NaidooD M Raidoo
Jul 5, 2008·Current Eye Research·Hidehiro OkuTsunehiko Ikeda
May 22, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Balwantray C Chauhan
May 12, 2005·Neuroscience Letters·Ianors IandievAndreas Bringmann
Jul 26, 2002·Journal of Glaucoma·Thomas YorioGanesh Prasanna
Aug 19, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shaoqing HeThomas Yorio
Mar 11, 2004·The European Journal of Neuroscience·F BlomstrandC Giaume
Apr 13, 2006·Journal of Neuroscience Research·F Blomstrand, C Giaume
Sep 26, 2007·Journal of Neuroscience Research·Claudia LehmannJürgen Engele
Aug 2, 2007·Izvestiia Akademii nauk. Seriia biologicheskaia·R R IslamovA K Murashov
Jun 12, 2012·Molecular Neurobiology·Soheila Karimi-Abdolrezaee, Rohini Billakanti
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M KerkovichJ Busciglio
Dec 21, 2004·Brain Pathology·Joanna RozyczkaJürgen Engele
Dec 25, 2003·Journal of Neuropathology and Experimental Neurology·P M HughesV H Perry
Sep 8, 2001·American Journal of Physiology. Cell Physiology·R BychkovC Giaume
Oct 12, 1999·The American Journal of Physiology·F BlomstrandL Rönnbäck
Feb 12, 2000·Progress in Neurobiology·M van den Buuse, K M Webber
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova

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