Expression of endothelin-converting enzyme, endothelin-1 and endothelin receptors at the site of percutaneous coronary intervention in humans

Journal of Hypertension
Nobuyuki ShiraiMakiko Ueda

Abstract

The repair process at the site of injury after percutaneous coronary intervention (PCI) is dominated by neointimal formation composed mainly of smooth muscle cells (SMC). Endothelin-1 (ET-1) is a powerful vasoconstrictor and SMC mitogen. Endothelin-converting enzyme (ECE) is the final key enzyme of endothelin processing. The effects of ET-1 are mediated by binding to endothelin type A (ETA) and endothelin type B (ETB) receptors. The ligand/receptor/ligand-producing system (ET system) could be involved in the pathogenesis of neointimal formation in humans. Fifteen post-PCI sites obtained at autopsy and eight atherectomy specimens obtained from restenotic sites were investigated using immunohistochemical single and double staining techniques. Frozen sections were stained with antibodies against ECE, ET-1, ETA and ETB receptors, SMC, macrophages and endothelial cells. At the early stage, less than 3 months after PCI, neointimal SMC were positive for ECE, ET-1, ETA and ETB receptors. The expression of ECE, ET-1, ETA and ETB receptors in these neointimal SMC decreased markedly from 6 months onwards. The ECE, ET-1, ETA and ETB receptor-positive cell areas were significantly (P < 0.005) greater in the first 3 months after PCI compared...Continue Reading

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Citations

May 29, 2012·Cardiovascular Research·Harold A Coleman, Helena C Parkington
Aug 18, 2012·Cardiology Research and Practice·Kento KitadaYasuo Matsumura
Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Takehisa SuekaneMakiko Ueda
Jul 10, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lian-Sheng WangBin Wang
Sep 13, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Fadia MayyasDavid R Van Wagoner
Aug 7, 2012·Journal of Pharmacological Sciences·Mamoru OhkitaYasuo Matsumura
Dec 27, 2015·Acta Physiologica·P M VanhoutteE H C Tang
Mar 30, 2018·Journal of Atherosclerosis and Thrombosis·Tomotaka YoshiyamaMakiko Ueda
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Petra KleinbongardGerd Heusch
Aug 21, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gordon A G McKenzieDaniel W Lambert
Sep 10, 2009·The Journal of Pharmacology and Experimental Therapeutics·Kento KitadaYasuo Matsumura
Nov 15, 2014·Oncology Reports·Kuo-Wang TsaiHing-Chung Lam
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Yue HongBadar A Usmani

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