PMID: 8601755Jan 1, 1996Paper

Expression of enhanced spontaneous and gamma-ray-induced apoptosis by lymphocytes of the wasted mouse

International Journal of Radiation Biology
G E WoloschakC R Libertin

Abstract

Mice bearing the autosomal recessive mutation wasted (wst/wst) display a disease pattern including increased sensitivity of lymphocytes to ionizing radiation, neurologic dysfunction, and immunodeficiency. Many of the features of this mouse model have suggested a premature or increased spontaneous frequency of apoptosis in thymocytes. Past work has documented an inability to establish cultured T cell lines, and abnormally high death rate of stimulated T cells in culture, and an increased sensitivity of T cells to the killing effects of ionizing radiations in the wst/wst mouse relative to controls. The experiments reported here were designed to examine splenic and thymic lymphocytes from the wasted and control mouse for signs of early apoptosis. Our results revealed enhanced expression of Rp-8 mRNA (which has been associated with apoptosis) in thymic lymphocytes and to a lesser extent in spinal cord in the wst/wst mouse relative to controls; expression of Rp-2 and Tcl-30 mRNA (also reported to be induced during apoptosis) were not detectable in spleen or thymus. Expression of Rp-2, Rp-8, and Tcl-30 mRNA in other affected tissues of the wasted mouse (brain and liver) were similar in the wasted mouse and controls. Thymus and spleen...Continue Reading

References

Feb 1, 1992·International Journal of Radiation Biology·M D StoryR E Meyn
Jul 31, 1992·Biochemical and Biophysical Research Communications·M C PeitschJ Tschopp
Jan 1, 1992·International Journal of Clinical & Laboratory Research·G MiglioratiC Riccardi
Oct 1, 1990·Cellular Immunology·M PadillaG E Woloschak
Aug 1, 1991·Molecular and Cellular Biology·G P OwensJ J Cohen
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C M AbbottJ Peters

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Citations

Jun 10, 2010·Molecular Cancer Research : MCR·Shruti DesaiKenneth L Wright

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis