Expression of enzymes of cyclooxygenase pathway and secretion of prostaglandin E2 and F2alpha by porcine myometrium during luteolysis and early pregnancy

Theriogenology
Anita FranczakB K Petroff

Abstract

Past studies of uterine prostaglandin (PGs) and pig reproduction have focused on endometrial rather than myometrial PGs. This study documents the synthesis and secretion of myometrial prostaglandins (PGs) in pigs and the involvement of oxytocin (OT) in these processes. Cyclooxygenase-2 (COX-2) expression was similar in myometrial explants from cyclic and pregnant pigs (days 14-16) and OT (10(-7) M) in vitro significantly increased COX-2 protein regardless of reproductive state. Basal expression of prostaglandin E2 synthase (PGES) was higher during pregnancy than during luteolysis. Conversely, prostaglandin F synthase (PGFS) was highest during luteolysis and lower in myometrium from gravid animals. OT had no influence on the expression of PGES and PGFS. In another tissue culture experiment, myometrial slices produced more PGE2 than PGF2alpha regardless of reproductive state of the female. OT stimulated PGE2 production in myometrium harvested during luteolysis and increased PGF2alpha production in all tissues examined. Progesterone (P4; 10(-5) M) blocked stimulatory effect of OT on myometrial PG release. Myometrial OTr mRNA was higher (P=0.03) during luteolysis than during pregnancy. (1) oxytocin increases myometrial COX-2 expres...Continue Reading

References

Jul 1, 1991·Journal of Reproduction and Fertility·B FlowersE V Caruolo
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Oct 4, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·J ParentM A Fortier
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Frank Hertelendy, Tamás Zakár
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Jul 9, 2005·Experimental Physiology·Stanislawa Stefanczyk-KrzymowskaMichał Radomski

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Citations

Sep 23, 2014·Functional & Integrative Genomics·Anita FranczakGenowefa Kotwica
Nov 30, 2006·Journal of Applied Genetics·Agnieszka OponowiczGenowefa Kotwica
Sep 10, 2013·Reproductive Biology·Anita FranczakGenowefa Kotwica
Nov 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·M Romek, J Karasinski
Mar 10, 2015·Reproduction, Fertility, and Development·Hilde NelisKatrien Smits
Jun 6, 2009·Experimental Biology and Medicine·Izabela Woclawek-PotockaDariusz Jan Skarzynski
May 3, 2016·General and Comparative Endocrinology·P BanerjeeR Chaube
Jun 20, 2017·Molecular Reproduction and Development·Agnieszka WaclawikAdam J Ziecik
Mar 19, 2009·The Journal of Reproduction and Development·Anita Franczak, Marek Bogacki
Aug 4, 2020·Reproduction in Domestic Animals = Zuchthygiene·Agata ZmijewskaAnita Franczak

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