PMID: 8605569Mar 1, 1996Paper

Expression of epidermal growth factor and its receptor in rabbits with ischaemic acute renal failure

Virchows Archiv : an International Journal of Pathology
T TairaS Koshikawa

Abstract

Urinary immunoreactive epidermal growth factor (EGF) levels decrease, and renal immunoreactive EGF levels increase in rats with ischaemic acute renal failure (ARF). We investigated the immunohistochemical localization of EGF and EGF receptor in rabbits with ischaemic ARF to clarify the significance of renal EGF. Male New Zealand White rabbits underwent right nephrectomy prior to a 60 min renal artery clamp. At 3, 6, 24, 48, 72 and 96 h after ischaemia, serum urea nitrogen and serum creatinine were determined. Guinea pig anti-rabbit EGF antibody and monoclonal anti-EGF receptor antibody were used for the primary incubation. EGF was immunolocalized to the ascending limb of Henle and the distal convoluted tubule in the normal right kidneys. However, in the post ischaemic left kidneys at 6, 24, 48 and 72 h, immunoreactivity of EGF was associated with proximal tubules. In the normal kidneys, antibody to EGF receptor reacted with distal tubules and collecting ducts. In the ischaemic kidneys, EGF receptor was localized in the basolateral membrane in the proximal tubules. The expression of EGF and EGF receptor in renal tubules may play an important role in repair following ischaemic renal damage.

Citations

Jul 6, 2004·Urological Research·Katsuhito MiyazawaShogo Katsuda
Jun 1, 1997·Kidney International·U M MalyankarC M Giachelli
Jan 20, 2004·Biochimica Et Biophysica Acta·William H Dantzler, Stephen H Wright
Jan 4, 2008·American Journal of Physiology. Renal Physiology·Shougang ZhuangRick G Schnellmann
Jan 25, 2008·American Journal of Physiology. Renal Physiology·Stephanie KrämerHarm Peters
Dec 19, 2008·American Journal of Physiology. Renal Physiology·Francisco J MendozaMariano Rodriguez
Oct 16, 2003·American Journal of Physiology. Renal Physiology·Silvina A BravoBirger Brodin
Sep 9, 2004·American Journal of Physiology. Renal Physiology·Ju-Young JungJin Kim
Jun 11, 1999·Immunology and Cell Biology·G GobéR B Endre
Jun 24, 2004·American Journal of Physiology. Renal Physiology·Shougang ZhuangRick G Schnellmann
Nov 23, 2006·The Journal of Biological Chemistry·Kyle A Rasbach, Rick G Schnellmann

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