Expression of epidermal growth factor and its receptor in equine placental tissues

Journal of Reproduction and Fertility
S N LennardF Stewart

Abstract

Northern blot and in situ hybridization techniques have demonstrated a marked increase in mRNA encoding epidermal growth factor (EGF) in the endometrium of mares, coincident with the start of interdigitation between the allantochorion and endometrium during placentation. In the present study, the unusually high EGF expression in the epithelium of the endometrial glands was shown to be maintained until at least day 250 of gestation (term = 320-340 days) in mares carrying normal horse conceptuses. However, in mares carrying failing donkey-in-horse pregnancies created by embryo transfer, EGF expression was severely retarded in those areas of the endometrium that were heavily infiltrated with lymphocytes and which showed a failure of placental development. Specific receptors for EGF were also detected in tissue homogenates from pregnant mares using 125I-labelled human EGF. Binding was high in the fetal membranes (allantochorion), both before implantation (days 30-34) and in the fully developed placenta (days 150-250), and was equivalent to the level of binding to homogenates of adult liver and kidney. Binding was much reduced in endometrial homogenates before implantation and from non-pregnant mares but increased after implantation...Continue Reading

Citations

Jan 22, 2003·Animal Reproduction Science·S Schäfer-Somi
Jul 12, 2007·Seminars in Immunopathology·Berthold Huppertz
May 15, 2010·Animal Reproduction Science·W R Twink Allen
Apr 1, 2008·Frontiers in Neuroendocrinology·Roberta Diaz BrintonJon Nilsen
Oct 13, 2007·Brain Research Reviews·Jun Ming WangRoberta Diaz Brinton
May 18, 2012·American Journal of Reproductive Immunology : AJRI·Berthold HuppertzMartin Gauster
Sep 16, 1999·The Journal of Veterinary Medical Science·K KusakabeY Kiso
Mar 11, 2015·Veterinary Research Communications·Emel AlanHakan Sağsöz
Mar 14, 2007·Placenta·G J BurtonD S Charnock-Jones
Jan 1, 2013·Annual Review of Animal Biosciences·D F AntczakW R Allen
May 1, 2001·American Journal of Veterinary Research·G M Ferreira-DiasJ R Silva
Jun 16, 1999·Molecular Reproduction and Development·C GerstenbergF Stewart
Jul 16, 2002·Equine Veterinary Journal·P L LorenzoA C Enders
Jun 19, 2021·Communications Biology·Tereza Cindrova-DaviesMargherita Y Turco

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