Expression of epidermal growth factor in the developing rat kidney

American Journal of Physiology. Renal Physiology
Ju-Young JungJin Kim

Abstract

Epidermal growth factor (EGF) is important in mammalian renal development. In our study, we investigated the detailed distribution and the time of the first appearance of EGF in developing rat kidney. Kidneys from embryonic 18 (E18)- and 20-day-old (E20) fetuses, postnatal 1 (P1)-, 3 (P3)-, 7 (P7)-, 14 (P14)-, and 21-day-old (P21) pups, and adults were processed for immunohistochemistry and electronmicroscopy. In adult rat kidney, EGF immunoreactivity was found in distal tubule including the thick ascending limb (TAL) and portion 1 of distal convoluted tubule (DCT1), whereas no EGF immunoreactivity was seen in portion 2 of distal convoluted tubule (DCT2) and connecting tubule. In developing kidney, EGF-positive cells first appeared at P3 and were localized in the middle portion of the differentiating TAL of the corticomedullary junction. By P7, the abundance of EGF expression had dramatically increased in the medullary TAL. Between P14 and P21, EGF immunoreactivity was found in the TAL and the DCT for the first time. However, EGF-positive and EGF-negative cells were in the TAL in developing rat kidney. EGF-positive cells did not differ from negative cells in the expression of sodium transport proteins or in the proliferation ra...Continue Reading

References

Jan 1, 1976·Kidney International·F Allen, C C Tisher
Jan 1, 1992·Biology of the Neonate·V H GattoneR M Klein
Sep 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E C SalidoD A Fisher
May 1, 1987·Pflügers Archiv : European journal of physiology·K YoshitomiM Imai
Aug 1, 1987·The American Journal of Physiology·J NormanL G Fine
May 1, 1988·Journal of Ultrastructure and Molecular Structure Research·J Dørup
Dec 1, 1988·The American Journal of Physiology·P R GoodyerR Rozen
Jan 1, 1986·The American Journal of Physiology·K M Madsen, C C Tisher
Jun 1, 1986·The American Journal of Physiology·K M Madsen, C C Tisher
Jan 1, 1987·Developmental Biology·M PoplikerC G Webb
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·E NexøM D Hollenberg
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Bachmann, P Mundel
Feb 1, 1995·Kidney International·S A OrellanaE D Avner
Jul 1, 1994·The American Journal of Physiology·S TsuruokaM Imai
Dec 30, 1993·Biochemical and Biophysical Research Communications·J Lakshmanan, V Eysselein
Mar 1, 1996·Virchows Archiv : an International Journal of Pathology·T TairaS Koshikawa
Jul 1, 1996·Kidney International·M D PlotkinS C Hebert
Sep 1, 1996·The American Journal of Physiology·C A EcelbargerM A Knepper
Oct 1, 1996·Kidney International·J LoffingB Kaissling
Oct 1, 1996·The American Journal of Physiology·J KimK M Madsen
Jan 1, 1997·The American Journal of Physiology·H Sakurai, S K Nigam
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·G H KimM A Knepper
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Jung-Ho ChaJin Kim
Mar 7, 2003·American Journal of Physiology. Renal Physiology·Johannes Loffing, Brigitte Kaissling

❮ Previous
Next ❯

Citations

Jan 25, 2011·Biochimica Et Biophysica Acta·Heather H WardTamara Roitbak
Nov 30, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zhiming HaoDaiming Fan
Jul 14, 2006·Kidney & Blood Pressure Research·Michiel SchreuderAns van Wijk
Oct 31, 2007·Apoptosis : an International Journal on Programmed Cell Death·H ServaisM-P Mingeot-Leclercq
Mar 18, 2010·The Journal of Veterinary Medical Science·Toshiya OkadaKeiko Kato
Oct 17, 2014·Clinical Journal of the American Society of Nephrology : CJASN·David B Mount
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
May 3, 2013·American Journal of Physiology. Renal Physiology·Alexander StaruschenkoTengis S Pavlov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.