Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Gustavo AlvarezHanlin L Wang

Abstract

Immunohistochemical detection of expression of the epidermal growth factor receptor (EGFR) has been utilized to identify eligible patients with solid malignant tumors, including colorectal adenocarcinoma, for monoclonal antibody therapy (eg, cetuximab). The EGFR status in squamous cell carcinoma of the anal canal, an uncommon malignancy traditionally treated with chemoradiation, has not been well investigated. In this study, 38 primary squamous cell carcinomas of the anal canal were immunohistochemically examined for EGFR expression and analyzed by fluorescence in situ hybridization (FISH) for EGFR gene copy numbers. The results showed a variable degree of EGFR expression in 21 (55%) tumors, among which 13 (62%) cases exhibited a 2+ to 3+ staining pattern according to the Dako EGFR phamDx interpretation guide. There were no significant differences among tumors stratified by stage, degree of keratinization, or tissue block storage times. FISH analysis showed that none of the 34 cases with interpretable results had EGFR gene amplification. Increased gene copy numbers due to polysomy 7 were seen in seven of 18 (39%) cases that expressed EGFR protein and four of 16 (25%) cases that did not (P=0.3876). Ten (56%) tumors with positive...Continue Reading

References

Sep 1, 1992·Cancer·S H Quan
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KoretzP Möller
Dec 1, 1990·The British Journal of Surgery·R J SteeleO Eremin
Apr 1, 1990·Gastroenterology·A PfeifferK Mann
Aug 1, 1987·The Journal of Pathology·M S BergerM D Waterfield
Feb 6, 1985·Nature·M B Sporn, A B Roberts
May 8, 1993·International Journal of Cancer. Journal International Du Cancer·M al-KasspoolesD G Beer
Mar 5, 1997·Journal of the National Cancer Institute·J Mendelsohn, Z Fan
Jun 9, 2001·Endocrine-related Cancer·C T KuanD D Bigner
Mar 27, 2002·Audiology & Neuro-otology·Ruth Anne EatockMelissa A Vollrath
Jul 6, 2002·Critical Reviews in Oncology/hematology·Lisa LicitraMichel Ducreux
Dec 13, 2002·Head & Neck·Allison Carter Ford, Jennifer Rubin Grandis
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Danielle W LuHanlin L Wang
Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fred R HirschWilbur A Franklin
Oct 8, 2003·Diseases of the Colon and Rectum·Reinhard KoppAndreas Pfeiffer
May 15, 2004·International Journal of Radiation Oncology, Biology, Physics·Roy S Herbst
Jun 5, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Luisa Veronese, Peter J O'Dwyer
Jun 23, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Derek AtkinsStephan Störkel
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry Q XiongJames L Abbruzzese
Jul 9, 2004·British Journal of Cancer·B F El-Rayes, P M LoRusso
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Aug 10, 2004·Cancer Science·Yuji HinodaKohzoh Imai
Oct 19, 2004·American Journal of Clinical Pathology·Jeffrey S RossGabriel N Hortobagyi
Jan 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ki Young ChungLeonard B Saltz
Feb 4, 2005·The New England Journal of Medicine·Jeffrey A Meyerhardt, Robert J Mayer
Feb 19, 2005·Current Oncology Reports·Emiliano Calvo, Eric K Rowinsky
Jun 1, 2005·American Journal of Clinical Pathology·Lyly H LêMalcolm J Moore
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara Burtness
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara BurtnessUNKNOWN Eastern Cooperative Oncology Group

❮ Previous
Next ❯

Citations

Sep 4, 2009·Cancer Chemotherapy and Pharmacology·Maria Giulia ZampinoGiuseppe Renne
Feb 25, 2010·Archives of Gynecology and Obstetrics·Linda HertleinKlaus Friese
Jul 29, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xiaoyan WangLiang Cheng
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hermann Brustmann
Jun 27, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hermann Brustmann
Dec 7, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hermann BrustmannAndreas Brunner
Jun 29, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ingeborg FraunholzClaus Rödel
Nov 3, 2012·Hematology/oncology Clinics of North America·Rob Glynne-Jones, Andrew Renehan
Dec 6, 2011·Clinics and Research in Hepatology and Gastroenterology·Suilane OliveiraChristophe Tournigand
Apr 1, 2011·Cancer Treatment Reviews·Faye Lim, Rob Glynne-Jones
Jan 23, 2008·American Journal of Clinical Pathology·Anne F BuckleySanjay Kakar
Jan 30, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P MaingonG Truc
May 23, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M MistrangeloP Cassoni
Jul 21, 2011·Journal of Oncology·Muhammad W SaifArmin Shahrokni
Mar 15, 2015·Journal of Gastroenterology and Hepatology·Yu-Hung SuTse-Ching Chen
Sep 23, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Eva Serup-HansenHanne Havsteen
Jun 13, 2013·International Journal of Radiation Oncology, Biology, Physics·Ingeborg FraunholzClaus Rödel
Apr 22, 2014·Human Pathology·Beatriz de Melo MaiaRafael Malagoli Rocha
Apr 28, 2016·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Orla A Houlihan, Brian D P O'Neill
Apr 8, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J H ChungS M Ali
Sep 20, 2016·Disease Markers·Vlad VoiculescuConstantin Caruntu
Jun 22, 2007·Chemical Biology & Drug Design·Estelle Marrer, Frank Dieterle
Nov 11, 2010·British Journal of Cancer·T LampejoS Cleator
Dec 28, 2019·International Journal of Molecular Sciences·Michele PietrafesaMatteo Landriscina
Jan 1, 2016·Oncology and Therapy·Rob Glynne-JonesMarcia Hall
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaoyan WangLiang Cheng
Jun 12, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Véronique VendrelyUNKNOWN for FFCD investigators/Collaborators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2022 Meta ULC. All rights reserved