PMID: 9537579Apr 16, 1998Paper

Expression of epidermal growth factor receptor in urinary bladder cancer metastases

International Journal of Cancer. Journal International Du Cancer
P BueP U Malmström

Abstract

Bladder cancers frequently exhibit an increased number of epidermal growth factor receptors (EGFR) in comparison to normal urothelium. The EGFR could potentially be a target for toxic conjugates. The aim of our study was to compare the expression of EGFR in metastases with concurrent or primary tumour in the urinary bladder using immunohistochemical techniques and a monoclonal antibody. Tumour material from 20 patients was investigated. The majority (13/20) of the metastases were homogeneously stained and showed a moderate to strong membranous staining for EGFR. The expression of EGFR in primary bladder tumours and metastases was similar. There was no indication that tumour tissue exposed to chemotherapy or radiation had a decreased number of EGFR. Targeting of the EGFR thus seems potentially applicable to metastatic disease.

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Citations

Aug 12, 2015·Current Opinion in Supportive and Palliative Care·Nimira S Alimohamed, Srikala S Sridhar
Feb 17, 2017·Therapeutic Advances in Medical Oncology·Sujata Narayanan, Sandy Srinivas
Apr 4, 2003·Cancer·Sana Al-Sukhun, Maha Hussain
May 17, 2005·BJU International·Ranveig RøtterudSophie D Fosså
Nov 18, 2008·Expert Opinion on Investigational Drugs·Alexandros LekasAndreas C Lazaris
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Apr 4, 2003·Cancer·E David CrawfordUNKNOWN Southwest Oncology Group
Aug 6, 2003·Critical Reviews in Oncology/hematology·Sana Al-Sukhun, Maha Hussain

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