PMID: 15226591Jul 1, 2004Paper

Expression of epidermal growth factor receptor (EGF-R), vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems in porcine oviduct and endometrium during the time of implantation

The Journal of Reproduction and Development
K WollenhauptKlaus-Peter Brüssow

Abstract

The oviduct and uterus provide the environment for the establishment of pregnancy. Among others, growth factor systems are involved in functional signaling interactions at the pre- and peri-implantation maternal-conceptus interface in pigs. Distinct regulation of epidermal growth factor Receptor (EGF-R), vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems and of bioactivation of EGF-R in porcine oviduct and endometrium during the estrous cycle, early pregnancy and during steroid replacement in ovariectomized gilts is summarized. Remarkable influences of ovarian steroids and EGF on the expression of specific markers of transcription and translation in these tissues are discussed. Known biological effects of the EGF, VEGF and FGF are related to cellular differentiation and angiogenesis. This suggests their involvement in the transformation of the endometrium into a decidua subsequently leading towards successful establishment of pregnancy. Peripheral steroids may exert their effects on epithelial cells both in a direct genomic manner or through mediators such as growth factors. The aim of our study was to draw specific attention to the paracrine regulation in the porcine endo...Continue Reading

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Citations

Dec 18, 2013·Cancer Treatment Reviews·Paula S Lee, Angeles Alvarez Secord
Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
Mar 18, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mariusz T SkowronskiSoren Nielsen
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Mar 11, 2015·Veterinary Research Communications·Emel AlanHakan Sağsöz
Dec 23, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Anthony Estienne, Christopher A Price
Jul 5, 2019·Journal of Cellular Biochemistry·Aydin Raei SadighMohammad Nouri
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Apr 23, 2020·International Journal of Molecular Sciences·Damian TanskiMariusz T Skowronski

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