PMID: 9429078Jan 16, 1998Paper

Expression of epidermal growth factor, transforming growth factor-alpha and their receptor in the human oesophagus

The Histochemical Journal
A CalabròC Surrenti

Abstract

Increasing evidence indicates that epidermal growth factor and transforming growth factor-alpha are involved in the maintenance of oesophageal mucosal integrity. However, their cellular origin and the exact localization of their receptor in the oesophagus are still unclear. Therefore, we examined the expression of the two growth factors and their shared receptor in the normal human oesophagus at both mRNA and protein level, by immunohistochemistry, in situ hybridization and reverse transcription-polymerase chain reaction. In addition to being expressed in the proliferative compartment of the oesophageal epithelium, the receptor was found in a variety of cells, including smooth muscle cells, submucosal gland cells and the epithelium lining their ducts. Immunohistochemically, the pattern of distribution of epidermal growth factor paralleled that of its receptor. In situ hybridization demonstrated epidermal growth factor mRNA expression in the oesophageal epithelium and submucosal glands. Additionally, amplified transcripts of predicted size were detected by reverse transcription-polymerase chain reaction, thus confirming that authentic transcripts of the growth factor exist in the normal human oesophagus. Transforming growth fact...Continue Reading

Citations

Jan 23, 2004·Nature Reviews. Cancer·John Condeelis, Jeffrey E Segall
Dec 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yizeng YangJonathan P Katz
Nov 2, 2005·Inflammopharmacology·Yasuhiro FujiwaraTetsuo Arakawa
Aug 8, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·G GonzalezH Mashimo
Sep 10, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·Alan Buchman
Apr 17, 2004·Journal of Gastroenterology and Hepatology·Yasuhiro FujiwaraTetsuo Arakawa
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alan L BuchmanJonathan Fryer

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