PMID: 8583007Jul 1, 1995Paper

Expression of epidermal growth factors and epidermal growth factor receptor in normal cycling human ovaries

Human Reproduction
M TamuraA Yajima

Abstract

Immunolocalization of transforming growth factor-alpha (TGF alpha), epidermal growth factor (EGF), cripto-1, amphiregulin and epidermal growth factor receptor (EGFR) was studied in 51 premenopausal human ovaries at various phases of the menstrual cycle. Localization of mRNA for TGF alpha and EGF was also studied by in-situ hybridization. Immunoreactive TGF alpha was observed predominantly in theca cells in 12 of 33 antral follicles in the follicular phase (6/14 dominant follicles, and 6/19 non-dominant) but not in any of the 18 follicles in the luteal phase or in primordial and pre-antral follicles. TGF alpha immunoreactivity was present predominantly in the luteinized granulosa cells in 13 of 15 corpora lutea in the luteal phase, which are considered to be active in steroidogenesis, but not in any of the regressed corpora lutea. Accumulation of TGF alpha mRNA hybridization signal was observed only in the theca cells in the follicles and luteinized theca cells in the ovaries that were immunohistochemically positive for TGF alpha. EGFR immunoreactivity was detected in 24 of 33 antral follicles in the follicular phase and in two of 18 follicles in the luteal phase but not in any of the corpora lutea. Immunoreactive EGF, cripto-1 ...Continue Reading

Citations

Aug 30, 2000·Molecular and Cellular Endocrinology·A Gougeon, D Busso
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S L HarrisJ K Scott
Mar 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jenna K Nyholt de PradaCatherine A VandeVoort
Jun 23, 2010·Reproductive Biology and Endocrinology : RB&E·Zheng Li-PingZheng Yue-Hui
Feb 23, 2008·Biochimica Et Biophysica Acta·Jacqueline M LafkyNita J Maihle
Aug 19, 2015·Molecular and Cellular Endocrinology·Karen L Reader, Elspeth Gold
Nov 15, 2008·Molecular and Cellular Endocrinology·M HerbetM Thomas
Mar 11, 2000·Journal of Receptor and Signal Transduction Research·A D EbertD S Salomon
Jan 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephanie PlanqueSudhir Paul
Aug 24, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Eray BalcanTayfur Cift
Sep 29, 2018·Luminescence : the Journal of Biological and Chemical Luminescence·Junbo LiWenlong Wei

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