Expression of epigenetic effectors in decidualizing human endometrial stromal cells

Molecular Human Reproduction
Giulia GrimaldiJan J Brosens

Abstract

Cyclic differentiation of human endometrial stromal cells (HESCs) into decidual cells is a highly coordinated process essential for embryo implantation and pregnancy. This differentiation process is closely recapitulated in culture upon exposure of purified HESCs to cyclic AMP and progesterone signaling. Mining of gene expression data revealed that HESCs express 147 genes coding for epigenetic effectors, 33 (22%) of which are significantly regulated (P < 0.05) upon decidualization. Among these are genes encoding for histone-modifying proteins and their cofactors, histone-binding proteins, histone variants, CpG-binding proteins and DNA methyltransferases (DNMTs). Interestingly, more than two-thirds of differentially expressed chromatin-modifying genes are down-regulated upon the transition from a proliferative to a differentiated HESC phenotype. Despite the strong regulation of DNMTs, colorimetric and long interspersed nuclear element 1 methylation assays did not show global changes in DNA methylation levels upon differentiation of HESCs. Taken together, the coordinated regulation of diverse effector molecules suggests that complex epigenetic modification at specific loci underpins the acquisition of a decidual endometrial pheno...Continue Reading

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Citations

Aug 8, 2015·Molecular Human Reproduction·Yanqing GengJunlin He
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Jul 29, 2019·Cellular and Molecular Life Sciences : CMLS·Shuangbo KongJinhua Lu
Jun 12, 2020·International Journal of Molecular Sciences·Shu-Wing NgErrol R Norwitz
Dec 10, 2019·Cellular and Molecular Life Sciences : CMLS·Hong LiuAihua Liao
Nov 18, 2020·Journal of Cellular and Molecular Medicine·Yao XiongYuanzhen Zhang
Dec 22, 2020·Frontiers in Physiology·Tamas Zakar, Jonathan W Paul
May 7, 2021·The Journal of Clinical Endocrinology and Metabolism·Stefania SalsanoFrancisco Domínguez
Jun 12, 2021·Journal of Reproductive Immunology·Shisu ZhaoYulan Dong
Jul 4, 2021·Tissue & Cell·Carlo TicconiAsgerally Fazleabas

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