Expression of epitopes of the tumour-associated glycoprotein 72 and clinicopathological correlations in mammary carcinomas

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
A ContegiacomoM R De Filippo

Abstract

We analysed the immunohistochemical expression pattern of the distinct carbohydrate epitopes of the TAG-72 molecule, defined by the monoclonal antibodies (MAbs) B72.3, CC-49 and CC-83, in 92 breast carcinomas of different histological type, and in other histological components identified in the mammary tissue samples studied. The results were correlated with the clinico-pathological characteristics of the tumours, and with their proliferative activity, assessed by thymidine labelling index (TLI). Expression of the TAG-72 epitopes was detected in all the tumour histotypes analysed, but patterns of immunoreactivity tended to vary in relation to type and level of differentiation. The comparative analysis of the reactivities of the three anti-TAG-72 MAbs revealed differences in their ability to recognise neoplastic lesions. MAb CC-49 reacted with the highest percentage of tumours (82%), and also tended to yield the highest percentages of immunoreactive cancer cells, while B72.3 and CC-83 reacted with lower percentages of tumours (respectively, 55 and 51%), and identified lower percentages of immunoreactive cells. High levels of expression of the three TAG-72 epitopes were detected in areas of in situ ductal carcinoma. Comparatively...Continue Reading

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Citations

Jan 1, 2012·Biomolecules·Sylvain JulienPhilippe Delannoy
Apr 22, 2003·International Journal of Cancer. Journal International Du Cancer·Aninda BasuUtpala Chattopadhyay
Feb 2, 1999·Oncogene·M SalvucciB Debuire
Aug 22, 1995·International Journal of Cancer. Journal International Du Cancer·A ContegiacomoL Frati

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