Expression of Epstein-Barr virus latent genes in oral epithelium: determinants of the pathogenesis of oral hairy leukoplakia

The Journal of Infectious Diseases
Dennis M WallingC Mark Nichols

Abstract

This retrospective study examined expression of Epstein-Barr virus (EBV) latent genes in oral epithelium from human immunodeficiency virus-seropositive subjects, to identify genes associated with the pathogenesis of oral hairy leukoplakia (HLP). Transcription of EBV latent genes was detected in tissues with productive EBV replication and, also, in normal oral epithelial tissues without EBV replication. Expression of the EBV EBNA-2 open-reading frame in oral epithelium was identified as an important cofactor associated with the pathogenesis of HLP. In vitro experiments suggested that a recombinant variant of the EBNA-2 gene may play a role in the pathogenesis of HLP, through modulation of EBNA-2 protein function.

Citations

May 31, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lertlakana BhoopatTanin Bhoopat
Mar 1, 2008·Head and Neck Pathology·Paulo Henrique Braz-SilvaMarina Helena Cury Gallottini de Magalhães
Apr 6, 2016·International Journal of Dentistry·Razia Abdool Gafaar KhammissaLiviu Feller
Sep 13, 2015·Annales de dermatologie et de vénéréologie·E VigariosV Sibaud
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Jul 11, 2006·Journal of Periodontal Research·J SlotsA Kubar
Dec 3, 2010·Journal of Cutaneous Pathology·Erica C RushingSteven D Billings
Apr 20, 2011·Journal of Medical Virology·Raymond P StoweDennis M Walling
Mar 25, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Pavels GordinsKonrad S Staines
Jan 24, 2015·Experimental & Molecular Medicine·Myung-Soo Kang, Elliott Kieff
Jul 9, 2014·Revista da Associação Médica Brasileira·Larissa SantosLedy Oliveira
Nov 27, 2008·International Journal of Surgical Pathology·Evangelia PiperiStefan Pambuccian
Mar 22, 2018·Cancers·Kathy H Y ShairVaughn S Cooper
May 5, 2006·Advances in Dental Research·T A HodgsonJ S Greenspan
Jul 19, 2019·Journal of Clinical Pathology·Jonathan R Kerr

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