PMID: 18184464Jan 11, 2008Paper

Expression of erythropoietin receptor in esophageal carcinoma and its correlation to microvessel density

Ai zheng = Aizheng = Chinese journal of cancer
Mei LiXiao-Qin Chen

Abstract

Erythropoietin receptor (EPO-R) is expressed in many kinds of tumors. The EPO/EPO-R signaling is involved in tumor cell proliferation, angiogenesis, and invasion. This study was to detect the expression of EPO-R in esophageal carcinoma, and explore its correlation to angiogenesis. The expression of EPO-R protein in 110 specimens of primary esophageal carcinoma was assessed by immunohistochemistry. The microvessels were immunohistochemically labeled with factor VIII-related antigen (FVIII-R Ag) to assess microvessel density (MVD). EPO-R was detected in all tumor tissues. It was expressed in cytoplasm and/or on cell membrane. Up-regulated EPO-R expression was correlated to poor differentiation (P<0.001) and lymph node metastasis (P=0.006). Increased MVD was correlated to poor differentiation (P<0.001), lymph node metastasis (P<0.001), advanced stage (III/IVA/IVB) (P=0.022), and smoking (P=0.029). The expression of EPO-R was positively correlated to MVD (r=0.618, P<0.01). EPO-R expressed generally in esophageal carcinoma. The level of EPO-R positively correlates to angiogenesis and progression of esophageal carcinoma. EPO might be an endogenous stimulant of angiogenesis during the progression of esophageal carcinoma.

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.