Expression of estrogen receptor alpha is associated with prolactin pituitary tumor prognosis and supports the sex-related difference in tumor growth.

European Journal of Endocrinology
E DelgrangeJ Trouillas

Abstract

A sex difference in the progression of prolactin (PRL) tumors has been disputed for years. To compare tumor characteristics and postoperative clinical course between men and women, and correlate data with estrogen receptor alpha (ERα (ESR1)) expression status. Eighty-nine patients (59 women and 30 men) operated on for a prolactinoma and followed for at least 5 years were selected. Tumors were classified into five grades according to their size, invasion, and proliferation characteristics. The ERα expression was detected by immunohistochemistry and a score (0-12) calculated as the product of the percentage of positive nuclei and the staining intensity. We found a significant preponderance of high-grade tumors among men and a lower surgical cure rate in men (23%) than in women (71%). Patients resistant to medical treatment were mainly men (7/8), six of whom showed tumor progression despite postoperative medical treatment, which led to multiple therapies and eventually death in three. The median score for ERα expression was 1 in men (range, 0-8) and 8 in women (range, 0-12) (P<0.0001). The expression of ERα was inversely correlated with tumor size (r=-0.59; P<0.0001) and proliferative activity. All dopamine agonist-resistant tumor...Continue Reading

References

Oct 19, 1978·The New England Journal of Medicine·J N CarterH G Friesen
Aug 1, 1979·Annals of Internal Medicine·A PontC B Wilson
Jan 3, 1991·The New England Journal of Medicine·R Mornex, B Hugues
May 23, 1985·The New England Journal of Medicine·M E Molitch
Nov 18, 1998·Mayo Clinic Proceedings·R D Calle-RodrigueD H Davis
Nov 18, 2000·Pituitary·G J KaptainE R Laws
Jun 1, 2001·Pituitary·G Segal-LiebermanI Shimon
Jan 5, 2002·Journal of Neuro-oncology·P NomikosR Fahlbusch
May 27, 2003·Surgical Neurology·Hiroshi NishiokaKiyohiro Akada
Jun 14, 2005·Molecular and Cellular Endocrinology·Sanjay KansraNira Ben-Jonathan
Jan 18, 2006·Pituitary·Marcello Delano Bronstein
Aug 5, 2006·Clinical Endocrinology·Felipe F CasanuevaAndrea Giustina
Nov 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Louis J GoorenMathijs C Bunck
Feb 9, 2008·Neuroendocrinology·Daniela B RadlDaniel Pisera
Apr 10, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J A BurdmanA E Bordón
Oct 24, 2008·Pituitary·Shrikrishna V AcharyaNalini S Shah
Apr 2, 2010·The Journal of Clinical Endocrinology and Metabolism·Masami OnoTomokatsu Hori
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Gérald RaverotThierry Brue
Mar 1, 2012·Clinical Endocrinology·B C WhitelawS J B Aylwin
Nov 20, 2012·The Journal of Clinical Endocrinology and Metabolism·Renata S AuriemmaAnnamaria Colao
Apr 16, 2013·The Journal of Clinical Endocrinology and Metabolism·K N SarwarJ K Powrie
Oct 4, 2013·European Journal of Endocrinology·Etienne DelgrangeDominique Maiter
Nov 22, 2013·Clinical Endocrinology·Marie-Eve DomingueDominique Maiter
Feb 19, 2014·European Journal of Endocrinology·Dominique Maiter, Etienne Delgrange
Apr 9, 2014·Endocrine·Ilan ShimonAriel Barkan

❮ Previous
Next ❯

Citations

Dec 31, 2017·Pituitary·Gerald RaverotEmmanuel Jouanneau
Oct 20, 2017·European Journal of Endocrinology·Gerald RaverotUNKNOWN European Society of Endocrinology
Jun 11, 2019·The Journal of International Medical Research·Yin-Xia SuXiao-Ming Gao
Sep 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Kristin Astrid ØysteseJens Bollerslev
Mar 1, 2016·Expert Review of Endocrinology & Metabolism·Sylvia L Asa, Shereen Ezzat
Sep 7, 2018·Case Reports in Endocrinology·Chandrika Jayakanthi SubasingheMárta Korbonits
Oct 17, 2019·Pituitary·Hélène LasolleGérald Raverot
Mar 20, 2020·International Journal of Molecular Sciences·Branka Šošić-JurjevićVerica Milošević
Feb 27, 2020·Cancers·Jacqueline TrouillasChiara Villa
Dec 25, 2017·Pituitary·Emilija Manojlovic-GacicOlivera Casar-Borota
Nov 7, 2019·Pituitary·Yona Greenman
Oct 24, 2019·Pituitary·M Beatriz S Lopes
Oct 16, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francisca Caimari, Márta Korbonits
Jan 22, 2021·Neurosurgery·Peter J KobalkaAline P Becker
Mar 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Farah Al SabieDiane Donegan
Mar 30, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mujdat KaraSelcuk Peker
Mar 29, 2021·Clinical Endocrinology·Nèle F LendersAnn I McCormack
Nov 28, 2018·Neuroendocrinology·Dominique Maiter
Apr 4, 2019·Neuroendocrinology·Jacqueline TrouillasGerald Raverot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved