PMID: 15248927Jul 14, 2004Paper

Expression of estrogen receptor and progesterone receptor in colorectal cancer: a quantitative study

Ai zheng = Aizheng = Chinese journal of cancer
Zhi-Wei ZhouPei-Rong Ding

Abstract

It was indicated that there was relationship between estrogen and colorectal cancer. Estrogen receptor (ER) and progesterone receptor (PR) were expressed in colorectal cancer tissue. They were measured using immunohistochemistry with various results,but there was little quantitative study. This study was designed to quantitatively measure the expression of ER and PR in tumor tissues and normal mucosas and analyze its relationship with clinicopathological parameters in colorectal cancer. ER and PR expression in cytoplasm and nucleus of tumor tissues and normal mucosas from 45 colorectal cancer patients were quantitatively measured using radioligand binding assay (RBA). ER and PR were expressed in all tumor tissues and normal mucosas. In cytoplasm, the ER expression level of tumor tissues was higher than that of normal mucosas; they were 7.96+/-3.69 fmol/mg protein and 4.34+/-2.84 fmol/mg protein (P< 0.01) respectively. And that was the same for PR expression; they were 3.89+/-2.64 fmol/mg protein and 2.50+/-1.73 fmol/mg protein(P< 0.01)respectively. In nucleus, the ER expression level of tumor tissues was higher than that of normal mucosas; they were 18.42+/-8.30 fmol/mg protein and 11.24+/-5.44 fmol/mg protein (P< 0.01)respecti...Continue Reading

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