Expression of estrogen receptor beta in the breast carcinoma of BRCA1 mutation carriers.

BMC Cancer
Maria M LitwiniukJan Breborowicz

Abstract

Breast cancers (BC) in women carrying mutations in BRCA1 gene are more frequently estrogen receptor negative than the nonhereditary BC. Nevertheless, tamoxifen has been found to have a protective effect in preventing contralateral tumors in BRCA1 mutation carriers. The identification of the second human estrogen receptor, ERbeta, raised a question of its role in hereditary breast cancer. The aim of this study was to assess the frequency of ERalpha, ERbeta, PgR (progesterone receptor) and HER-2 expression in breast cancer patients with mutated BRCA1 gene and in the control group. The study group consisted of 48 women with BRCA1 gene mutations confirmed by multiplex PCR assay. The patients were tested for three most common mutations of BRCA1 affecting the Polish population (5382insC, C61G, 4153delA). Immunostaining for ERalpha, ERbeta and PgR (progesterone receptor) was performed using monoclonal antibodies against ERalpha, PgR (DakoCytomation), and polyclonal antibody against ERbeta (Chemicon). The EnVision detection system was applied. The study population comprised a control group of 120 BC operated successively during the years 1998-99. The results of our investigation showed that BRCA1 mutation carriers were more likely to h...Continue Reading

References

Jul 25, 1990·Nucleic Acids Research·F GiannelliA Yoshioka
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
May 15, 1997·The New England Journal of Medicine·M KrainerD A Haber
Jul 31, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D K GaffneyL A Cannon-Albright
Oct 22, 1998·Human Pathology·B J LynchD K Gaffney
Jul 25, 2000·Journal of the National Cancer Institute·A M Martin, B L Weber
Dec 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Stoppa-LyonnetB Asselain
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Miguel de la HoyaTrinidad Caldés
May 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunil R LakhaniDouglas F Easton
May 17, 2002·The Journal of Pathology·Valerie Speirs
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria Grazia DaidoneMamoun Younes
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Oct 2, 2003·Journal of the National Cancer Institute·William D FoulkesLars A Akslen
May 6, 2004·Journal of the National Cancer Institute·Petra van der GroepPaul J van Diest
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Majida Esslimani-SahlaHenri Rochefort
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten A HoppSuzanne A W Fuqua
Jun 28, 2005·Breast Cancer Research and Treatment·B GórskiJ Lubiński
Sep 21, 2005·Endocrine-related Cancer·E M RosenC Isaacs
May 27, 2006·Endocrine-related Cancer·Leigh C Murphy, Peter H Watson
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sofia K Gruvberger-SaalMårten Fernö
Jan 1, 2004·Hereditary Cancer in Clinical Practice·Emiliano HonradoJosé Palacios

❮ Previous
Next ❯

Citations

Oct 14, 2010·Virchows Archiv : an International Journal of Pathology·Pawel DomagalaWenancjusz Domagala
Feb 22, 2011·Cellular Oncology (Dordrecht)·Petra van der GroepPaul J van Diest
Oct 14, 2014·Expert Opinion on Therapeutic Targets·Anselmo PapaFederica Tomao
Sep 10, 2013·American Journal of Surgery·Jennifer SteimanOnsi Kamel
Apr 16, 2015·BioMed Research International·Nalo HamiltonRichard Pietras
Aug 16, 2016·European Journal of Human Genetics : EJHG·Dominique Stoppa-Lyonnet
Aug 7, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kelly-Anne PhillipsJohn L Hopper
Jun 8, 2018·The Journal of Pathology·Marieke van de VenJos Jonkers
Jul 12, 2013·International Journal of Oncology·Sebastien TaurinRhonda J Rosengren
Sep 19, 2020·Biomarker Research·Yujing Zhou, Xingdang Liu
Sep 5, 2020·International Journal of Molecular Sciences·Ece Cakiroglu, Serif Senturk
Jan 29, 2019·Frontiers in Endocrinology·Rainer GirgertCarsten Gründker
Oct 30, 2020·Cells·Oliver TreeckOlaf Ortmann

❮ Previous
Next ❯

Datasets Mentioned

BETA
AB1410

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

© 2022 Meta ULC. All rights reserved